Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 404-290-3 | CAS number: 7216-95-7
Additional toxicological data
Administrative data
- Endpoint:
- additional toxicological information
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Study period:
- 1975
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Published data, information on methods and results is sufficient to make an assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Removal of manganese by chelating agents from brain and liver of manganese treated rats: An in vitro and in vivo study
- Author:
- Tandon SK
- Year:
- 1 975
- Bibliographic source:
- Toxicol., 5 (2), 237-241
Materials and methods
- Type of study / information:
- Some chelating agents were examined for their ability to remove manganese from brain and liver (in vivo) and their sub-cellular fractions (in-vitro) of rats treated with manganese sulphate
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Not applicable
- GLP compliance:
- not specified
Test material
- Reference substance name:
- N-carboxymethyliminobis(ethylenenitrilo)tetra(acetic acid)
- EC Number:
- 200-652-8
- EC Name:
- N-carboxymethyliminobis(ethylenenitrilo)tetra(acetic acid)
- Cas Number:
- 67-43-6
- Molecular formula:
- C14H23N3O10
- IUPAC Name:
- 2-[bis[2-(bis(carboxymethyl)amino)ethyl]amino]acetic acid
- Details on test material:
- - Name of test material: DTPA
Constituent 1
Results and discussion
Any other information on results incl. tables
Though all the chelating agents were found to be capable of mobilizing manganese to a variable degree, CDTA and PAS were particularly effective in vitro while the former together with NTA and DTPA were most successful in vivo
Applicant's summary and conclusion
- Conclusions:
- Some chelating agents were examined for their ability to remove manganese from brain and liver (in vivo) and their sub-cellular fractions (in-vitro) of rats treated with manganese sulphate. Though all the chelating agents were found to be capable of mobilizing manganese to a variable degree, CDTA and PAS were particularly effective in vitro while the former together with NTA and DTPA were most successful in vivo
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