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EC number: 222-182-2 | CAS number: 3380-34-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
Acutely very toxic for aquatic organisms
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 0.191 mg/L
Additional information
Three studies on the acute toxicity of Triclosan to aquatic invertebrates are available. In a study according to OECD guideline 202 Daphnia magna was exposed to the substance for 48 h in a static test system. Regarding the mobility of D. magna an EC50 of 0.191 mg/l was recorded (mean measured; Ciba-Geigy 1990). A second test on D. magna was set up according to U.S. EPA guideline No. 660/3-75-009. An EC50 of 0.39 mg/l (nominal) was determined after 48 hours of exposure. In a further test the correlation between acute toxicity and pH was tested. Ceriodaphnia dubia was exposed to Triclosan at four different pH (7.0, 7.5, 8.0, 8.5). The mortality of C. dubia was recorded after 48 hours. The LC50 values decreased with increasing pH. Following LC50 values were reported (measured): 0.13 mg/l (pH 7.0), 0.18 mg/l (pH 7.5), 0.24 mg/l (pH 8.0), 0.41 mg/l (pH 8.5) (Ciba-Geigy 1991).
The study by Ciba-Geigy (1990) was selected as key study as this study was performed with the preferred species Daphnia magna (REACH Regulation, Annex VII, 9.1.1) and showed the highest sensitivity at the tested pH range of 8.1 to 8.4. The study by Ciba-Geigy (1991) resulted in a similar EC50 at this pH range but was performed with a different species (Ceriodaphnia dubia). Only testing at a lower pH than the standard medium resulted in a higher sensitivity.
The acute toxicity of the metabolite methyltriclosan was determined according to OECD 202. The 48 -h EC50 was above the water solubility limit under test conditions of 0.18 mg/L (Ciba, 2006).
The following table gives an overview on the available reliable data on acute effects of Triclosan on aquatic invertebrates.
Reference |
RL |
Species |
Exp. |
Effect level |
Value (µg/L) |
Nom./ meas. |
Fw/ Mar. |
Remark |
Triclosan |
||||||||
Ciba-Geigy AG (1990). Proj. No. 262923 |
1 |
Daphnia magna |
48 h |
EC50 |
191 |
meas. |
fw |
mobility |
Tamura et al. (2013) |
2 |
Daphnia magna |
48 h |
EC50 |
180 |
meas. |
fw |
mobility |
Harada et al. (2008) |
2 |
Daphnia magna |
48 h |
EC50 |
260 |
nom. |
fw |
mobility |
Peng et al. (2013) |
2 |
Daphnia magna |
48 h |
LC50 |
330 |
nom. |
fw |
mortality |
Wang et al. (2013) |
2 |
Daphnia magna |
48 h |
LC50 |
338 |
nom. |
fw |
mortality |
Procter & Gamble (1990). Rep. No. 38656 |
2 |
Daphnia magna |
48 h |
EC50 |
390 |
nom. |
fw |
mobility |
Orvos et al. (2002) |
2 |
Daphnia magna |
48 h |
EC50 |
390 |
nom. |
fw |
mortality |
Ciba-Geigy Corp. (1991). Rep. No. 1011-0691-6278-132 |
2 |
Ceriodaphnia sp. |
48 h |
LC50 |
130 |
meas. |
fw |
mortality, pH 7.0 |
Ciba-Geigy Corp. (1991). Rep. No. 1011-0691-6278-132 |
2 |
Ceriodaphnia sp. |
48 h |
LC50 |
180 |
meas. |
fw |
mortality, pH 7.5 |
Ciba-Geigy Corp. (1991). Rep. No. 1011-0691-6278-132 |
2 |
Ceriodaphnia sp. |
48 h |
LC50 |
240 |
meas. |
fw |
mortality, pH 8.0 |
Ciba-Geigy Corp. (1991). Rep. No. 1011-0691-6278-132 |
2 |
Ceriodaphnia sp. |
48 h |
LC50 |
410 |
meas. |
fw |
mortality, pH 8.5 |
Wang et al. (2013) |
2 |
Chironomus plumosus |
96 h |
LC50 |
2890 |
nom. |
fw |
mortality |
Wang et al. (2013) |
2 |
Limnodrilus hoffmeisteri |
96 h |
LC50 |
2046 |
nom. |
fw |
mortality |
Wang et al. (2013) |
2 |
Neocaridina denticulata sinensis |
96 h |
LC50 |
772 |
nom. |
fw |
mortality |
De Lorenzo et al. (2008) |
2 |
Palaemonetes pugio |
96 h |
LC50 |
154 |
nom. |
Mar. |
shrimp larvae |
Kim et al. (2009) |
2 |
Thamnocephalus platyurus |
24 h |
EC50 |
470 |
nom. |
Mar. |
mobility |
Anselmo et al. (2011) |
2 |
Psammechinus miliaris |
72 h |
EC50 |
78-89 |
nom. |
Mar. |
morphology of larvae |
Hwang et al. (2014) |
2 |
Strongylocentrotus nudus |
72 h |
EC50 |
286 |
nom. |
Mar. |
embryonic development |
Cortez et al. (2012) |
2 |
Perna perna |
48 h |
IC50 |
135 |
nom. |
Mar. |
embryo-larval development |
Methyltriclosan |
||||||||
Ciba Specialty Chem. (2006). Rep. No.A34931 |
1 |
Daphnia magna |
48 h |
EC50 |
> 180 |
nom. |
fw |
mobility; EC50 above the solubility limit |
Exp.: exposure duration; Fw.: freshwater; Mar.: marine water; Meas.: measured; Nom.: nominal; RL: Reliability
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