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EC number: 222-182-2 | CAS number: 3380-34-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Neurotoxicity
Administrative data
Description of key information
Only one 2 week neurotoxicity study is available, which has been conducted in the early seventies, i.e. prior to the implementation of technical guidelines for study conduct and at a time where GLP was not mandatory (Ciba-Geigy Ltd PH 2.632). The informative value of this study has to be considered with caution.
Key value for chemical safety assessment
Additional information
A 2-week neurotoxicity study was conducted with triclosan offered orally (unspecified) to rat a doses of 0, 100, 300, 1000, 2000 mg/kg bw/day (Ciba-Geigy Ltd PH 2.632). 17 deaths in high-dose group (5 of these were sacrificed due to moribund condition) as well as decreased body weights in the high dose group were reported. Dose-dependent inhibition of movement, decreased muscular tone, polydipsia and polyuria were reported at dose levels of 300 mg/kg bw/day and higher. Clinical signs were most severe in the high-dose group and also included spastic respiration for several animals. No difference in brain
weights between treated and controls (no other organ weights were measured). No histopathological changes in the brain or sciatic nerve of treated or control animals were observed (no other tissues evaluated).
The results of this study indicate a NOEL of 100 mg/kg body weight/day for triclosan in the rat. There was no evidence of neuropathology at any dose level, as examined in the brain and sciatic nerve tissues. The investigators concluded that triclosan produces no specific neurotoxic effects in the rat; however, the reasons for observations of clinical signs consistent with possible neurotoxicity (e.g., hypoactivity, decreased muscular tone) are unclear.
Moreover, it has to be noticed that triclosan bears no structural similarity to organophosphates, carbamates or other known inducers of delayed neurotoxicity, and acute and repeated-dose studies in several species did not indicate the occurrence of neurotoxic effects. Thus, the findings reported in the study above have to be considered with caution.
Justification for classification or non-classification
Since triclosan bears no structural similarity to organophosphates, carbamates or other known inducers of delayed neurotoxicity and since acute and repeated-dose studies in several species did not indicate the occurrence of neurotoxic effects, there is no need to classify triclosan.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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