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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
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Diss Factsheets
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EC number: 289-064-0 | CAS number: 85959-68-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
The toxicity of DTPA to microorganisms was assessed in several studies, including OECD 209 activated sludge respiration inhibition tests, and several biodegradation screening tests. In the activated sludge respiration inhibition study the 3-hour EC50 was greater than 1280 mg/L for DTPA-FeHNa, corresponding to 1313 DTPAFe(NH4)2. A NOEC was established at 400 mg/L DTPA acid, corresponding to 488 mg/L DTPA-Fe(NH4)2.
Key value for chemical safety assessment
Additional information
In an OECD 209 test, a 3 -hour EC50 value could not be determined for DTPA-FeHNa, since only minor effects were observed at 1280 mg/L, the highest concentration tested. This was confirmed by DTPA acid in another OECD 209 test. In an OECD 302B inherent biodegradation test, no inhibition of activated sludge inoculum was observed at 100 mg/L DTPA acid (123 mg/L DTPA-Fe(NH4)2). In batch biodegradation studies using microbial inocula from pulp mill activated sludge, municipal activated sludge, and soil, no microbial inhibition was reported for DTPA acid concentrations of 400 mg/L (488 mg/L DTPA-Fe(NH4)2). Using pulp mill activated sludge pre-exposed to DTPA, no inhibition was reported in reaction mixtures containing 725 mg/L DTPA acid (886 mg/L DTPA-Fe(NH4)2). These results are consistent with the structurally similar compound EDTA, where EDTA did not significantly inhibit the respiration of activated sludge in an OECD 209 test up to a nominal concentration of 500 mg/L (EC20, EC50, EC80 >500 mg/L).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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