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EC number: 206-022-9 | CAS number: 288-88-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
-Skin irritation : 1,2,4-triazole is not irritant in rabbit (according to Thyssen(1976) and Procopio (1992) studies.
-Eye irritation : 1,2,4-triazole is irritant for eyes in rabbit (according toThyssen (1976) and Procopio (1992) studies.
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1976
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: GLP Guideline study without detailed documentations
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Version / remarks:
- reliability scoring was based on 2002 guideline
- Deviations:
- yes
- Remarks:
- Chemical characteristics of test substance and temperature, light cycle, and humidity not provided; grading scale of irritation not included and an incorrect number of animals were used
- GLP compliance:
- no
- Remarks:
- study pre-dates GLP requirements
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: from the breeder Winkelmann (Borchen)
- Age at study initiation: no data
- Weight at study initiation: 3-4kg
- Fasting period before study: no data
- Housing: singly in standard rabbit cages
- Diet (e.g. ad libitum): Rabbit food 222 (Hoeing co.), ad libitum
- Water (e.g. ad libitum): not precised, ad libitum
- Acclimation period: no data
ENVIRONMENTAL CONDITIONS: no data - Type of coverage:
- occlusive
- Preparation of test site:
- other: hairless skin on ears
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- Small cellulose patches (1.5 cm X 1.5 cm) with 500 mg of the test substance applied was attached to skin of the ears of rabbits with an adhesive dressing for 24 hours.
- Duration of treatment / exposure:
- 24 hours of exposure
- Observation period:
- 7 days
- Number of animals:
- 2
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 24 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 24 h
- Score:
- 0
- Max. score:
- 4
- Irritant / corrosive response data:
- A score of 0 for all time points, factors and animals.
- Other effects:
- No changes for up to 7 days after application.
- Interpretation of results:
- not irritating
- Conclusions:
- In this study, mean erythema score and mean edema score are equal to 0 : 1,2,4-triazole is not a skin irritant.
- Executive summary:
A non GLP Acute Dermal Irritation / Corrosion test comparable to OECD 404 guideline was carried out with 1,2,4 -triazole. The test substance was applied undiluted on a occlusive patch on hairless skin on ears. The test material induced no erythema and no edema on two animals.
Under the experimental conditions, the test substance is not irritant and is not classified according to regulation EC no.1272/2008 (CLP).
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1976
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study without detailed documentation
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Version / remarks:
- reliability scoring based on 2002 guideline
- Deviations:
- yes
- Remarks:
- Source, purity, chemical characteristics of test substance, temperature, light cycle, and humidity not provided; grading scale for irritation not reported
- GLP compliance:
- no
- Remarks:
- study pre-dates GLP requirements
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: from the breeder Winkelmann (Borchen)
- Age at study initiation: no data
- Weight at study initiation: 3-4kg
- Fasting period before study: no data
- Housing: singly in standard rabbit cages
- Diet (e.g. ad libitum): Rabbit food 222 (Hoeing co.), ad libitum
- Water (e.g. ad libitum): not precised, ad libitum
- Acclimation period: no data
ENVIRONMENTAL CONDITIONS: no data - Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- Test article was instilled into the conjuctival sac of the left eye of 2 rabbits at a dose of 50 mg/animal.
- Duration of treatment / exposure:
- Single administration
- Observation period (in vivo):
- 7 days
- Number of animals or in vitro replicates:
- 2
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Remarks:
- 2 rabbits
- Time point:
- 24/48 h
- Score:
- 0.5
- Max. score:
- 4
- Reversibility:
- fully reversible
- Remarks on result:
- other: (1 rabbit)
- Irritation parameter:
- iris score
- Basis:
- mean
- Remarks:
- 2 rabbits
- Time point:
- 24/48 h
- Score:
- 0.5
- Max. score:
- 2
- Reversibility:
- fully reversible
- Remarks on result:
- other: (1 rabbit)
- Irritation parameter:
- conjunctivae score
- Remarks:
- (redness)
- Basis:
- mean
- Remarks:
- 2 rabbits
- Time point:
- 24/48 h
- Score:
- 2.5
- Max. score:
- 4
- Reversibility:
- fully reversible
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Remarks:
- 2 rabbits
- Time point:
- 24/48 h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible
- Remarks on result:
- other: (1 rabbit)
- Irritant / corrosive response data:
- One hour after application intense reddening and a very intense swelling of the conjectivae of the treated eyes had developed. 24 hours after application intense reddening and moderate swelling of the conjuctivae was still present. In one animal, there was still slight redness and swelling of the conjuctivae 5 days after application, while it was normal in the other animal. The conjuctivae of both animals were normal after 7 days. During the first and second days after application, a slight, dispersed, diffuse opacity of the cornea was observed. The iris was slightly reddened and swollen.
- Interpretation of results:
- Category 2 (irritating to eyes) based on GHS criteria
- Conclusions:
- The authors concluded that 1,2,4-triazole has a irritant effect on the mucous membrane.
- Executive summary:
A non GLP comparable Guideline 405 (Acute Eyes Irritation / Corrosion) test was carried out with 1,2,4 -triazole.
Undiluted test article was instilled into the conjuctival sac of the left eye of 2 rabbits at a dose of 50 mg/animal.
One hour after application intense reddening and a very intense swelling of the conjectivae of the treated eyes had developed. 24 hours after application intense reddening and moderate swelling of the conjuctivae was still present. In one animal, there was still slight redness and swelling of the conjuctivae 5 days after application, while it was normal in the other animal. The conjuctivae of both animals were normal after 7 days. During the first and second days after application, a slight, dispersed, diffuse opacity of the cornea was observed. The iris was slightly reddened and swollen.
Under the experimental conditions, the test substance is irritant and is classified in category 2 according to regulation EC no.1272/2008 (CLP).
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Skin irritation :
A GLP OECD 404 key study (Procopio, 1992) was carried out with 1, 2, 4 triazole. No edema and no other erythema was observed during the study. In the abraded skins, very slight erythema was observed on two application sites at 24 hr and on one application site at 72 hr. No other erythema and no edema was observed during the study. The test item was shown to be slightly irritant but was not sufficient for classification.
A non GLP Acute Dermal Irritation / Corrosion test with restricted limitations was carried out with 1,2,4 -triazole (Thyssen, 1976) . The test substance was applied undiluted on a occlusive patch on hairless skin on ears. The test material induced no erythema and no edema on two animals (scores = 0).
Eye irritation :
In a GLP key OECD 405 study (Procopio, 1992). 1,2,4, Triazole is categorized as SUBSTANTIALLY IRRITATING to the eye (i.e. ocular effects reversible within 21 days but not 7 days after dosing in rabbits).
A supportive non GLP OECD Guideline 405 (Acute Eyes Irritation / Corrosion) test was carried out with 1,2,4 -triazole.
Undiluted test article was instilled into the conjuctival sac of the left eye of 2 rabbits at a dose of 50 mg/animal.
One hour after application intense reddening and a very intense swelling of the conjectivae of the treated eyes had developed. 24 hours after application intense reddening and moderate swelling of the conjuctivae was still present. In one animal, there was still slight redness and swelling of the conjuctivae 5 days after application, while it was normal in the other animal. The conjuctivae of both animals were normal after 7 days. During the first and second days after application, a slight, dispersed, diffuse opacity of the cornea was observed. The iris was slightly reddened and swollen.
Effects on eye irritation: irritating
Justification for classification or non-classification
Skin irritation :
1,2,4 -triazole is not a skin irritant and is not classified for this endpoint according to Regulation EC no.1272/2008 (CLP) and according to the EU Directive 67/548/EEC.
Eye irritation :
1,2,4 -triazole is a eye irritant and is classified for this endpoint in category 2 (H319: Causes serious eye irritation) according to Regulation EC no.1272/2008 (CLP) and "R36" according to the EU Directive 67/548/EEC.
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