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EC number: 211-750-5 | CAS number: 693-36-7
Toxicity to soil macroorganisms except arthropods
Administrative data
Link to relevant study record(s)
Description of key information
Toxic effects have been observed in a study with soil macroorganisms. In a chronic study with earthworms adverse effects on reproduction occurred.
Key value for chemical safety assessment
- Long-term EC10, LC10 or NOEC for soil macroorganisms:
- 39 mg/kg soil dw
Additional information
The toxicity to terrestrial macroorganisms was determined in a study according to OECD guideline No 222 and in compliance with GLP criteria.
Two 56-day reproduction tests withEisenia fetidawere performed. Forty worms (ten per replicate, four replicates) were exposed to each concentration, whereas 80 worms (ten per replicate, eight replicates) were exposed to an untreated control. In the first reproduction test concentrations of 63, 125, 250, 500 and 1000 mg/kg d.s. (dry soil) were tested, whereas in the second test worms were exposed to 1.0, 2.5, 6.3, 16 and 39 mg/kg d.s. The surviving worms were removed after 28 days of exposure and the produced cocoons were allowed to hatch for a period of 28 days. The following endpoints were recorded:
·Biomass of adult animals: day 0 and 28
·Mortality of adult worms: day 28
·Reproduction: day 56
Both tests met the acceptability criteria prescribed by the study plan and were considered valid. Under the conditions of the present study, the substance did not reduce the reproduction of Eisenia fetida at a nominal concentration of 39 mg/kg d.s. after 56 days of exposure (NOEC).
The 56-day EC50 for reproduction exceeded the highest concentration tested, i.e. was above 1000 mg/kg d.s.
The 28-d NOEC for mortality and weight reduction was 1000 mg/kg d.s. All validity criteria were met.
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