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Diss Factsheets
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EC number: 204-800-2 | CAS number: 126-73-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://poisoncentres.echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Repeated dose toxicity: inhalation
Administrative data
- Endpoint:
- sub-chronic toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: few experimental details - original in Russian
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- publication
- Title:
- No information
- Author:
- Kalinina NI
- Year:
- 1 971
- Bibliographic source:
- Gig. Tr. Prof. Zabol. 15, 30-33
Materials and methods
- Principles of method if other than guideline:
- rats were exposed to vapour of tributyl phosphate at concentrations of 13.5+-2.5 and 4.8 mg/m³ for 4 month, 5 times per week, 5 hours daily. the cholinesterase activity and biochemical parameters were examined.
Test material
- Reference substance name:
- Tributyl phosphate
- EC Number:
- 204-800-2
- EC Name:
- Tributyl phosphate
- Cas Number:
- 126-73-8
- Molecular formula:
- C12H27O4P
- IUPAC Name:
- tributyl phosphate
- Details on test material:
- no data
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- not specified
- Vehicle:
- other: no data
- Remarks on MMAD:
- MMAD / GSD: no data
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- 4 months
- Frequency of treatment:
- 5 days/week, 5 hours/day
Doses / concentrations
- Remarks:
- Doses / Concentrations:
5.1 or 13.6 mg/m3
Basis:
- No. of animals per sex per dose:
- no data
- Control animals:
- not specified
- Details on study design:
- Post-exposure period: 1 months
Results and discussion
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
RS-Freetext:
in the high concentration decrease of cholinesteraseactivity to 33 % after 3 months, effects on physiological
and biochemical parameters esp. of the liver. The
cholinesterase activity retained to normal in the
postexposure period. In the low concentration no effect on
cholinesterase activity (no further data).
Applicant's summary and conclusion
- Executive summary:
Rats were exposed to vapour of tributyl phosphate at concentrations of 13.5+-2.5 amd 4.8 mg/m³ for 4 month, 5 times per week, 5 hours daily. The cholinesterase activity and biochemical parameters were examined.
in the high concentration decrease of cholinesteraseactivity to 33 % after 3 months, effects on physiological
and biochemical parameters esp. of the liver. The cholinesterase activity retained to normal in the
postexposure period. In the low concentration no effect on cholinesterase activity. A NO(A)EL was not stated.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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