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EC number: 200-834-7 | CAS number: 75-04-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Repeated dose toxicity: inhalation
Administrative data
- Endpoint:
- repeated dose toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Pathological report of inhalation toxicity study performed by Virginia Chem in 1984. Provides summarized histopathological results.
- Remarks:
- This is a narrative of the results from a 10 day exposure to ethylamine in Fischer 344 rats. Limited information provided.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 984
- Report date:
- 1984
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- not specified
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- Ethylamine
- EC Number:
- 200-834-7
- EC Name:
- Ethylamine
- Cas Number:
- 75-04-7
- Molecular formula:
- C2H5NH2
- IUPAC Name:
- ethanamine
- Details on test material:
- - Name of test material (as cited in study report): Ethylamine
- Analytical purity: no data
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Fischer 344
- Sex:
- male/female
Administration / exposure
- Route of administration:
- inhalation
- Type of inhalation exposure:
- not specified
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- 10 days and 120 days
- Frequency of treatment:
- no data
Doses / concentrationsopen allclose all
- Dose / conc.:
- 10 ppm (nominal)
- Remarks:
- 120 days exposure
- Dose / conc.:
- 100 ppm (nominal)
- Remarks:
- 120 days exposure
- Dose / conc.:
- 250 ppm (nominal)
- Remarks:
- 10 days exposure
- Dose / conc.:
- 1 000 ppm (nominal)
- Remarks:
- 10 days exposure
- Dose / conc.:
- 1 000 ppm (nominal)
- Remarks:
- 120 days exposure
- No. of animals per sex per dose:
- 10 days exposure: 5 animals
120 days exposure: 30 animals (16 males and 17 females examined at necroscopy) - Control animals:
- not specified
Results and discussion
Results of examinations
- Body weight and weight changes:
- not specified
- Food consumption and compound intake (if feeding study):
- not specified
- Food efficiency:
- not specified
- Water consumption and compound intake (if drinking water study):
- not specified
- Ophthalmological findings:
- not specified
- Haematological findings:
- not specified
- Clinical biochemistry findings:
- not specified
- Urinalysis findings:
- not specified
- Behaviour (functional findings):
- not specified
- Immunological findings:
- not specified
- Organ weight findings including organ / body weight ratios:
- not specified
- Gross pathological findings:
- effects observed, treatment-related
- Description (incidence and severity):
- 10 days exposure:
- Slight to moderate necrotizing inflammation of the nasal cavity in 3/5 male rats in the 250 ppm group and in 5/5 male rats in the 1000 ppm group.
- Moderate thymic atrophy after 1000 ppm expsore for all animals
120 days expsoure/ 500 ppm:
- Moderate to marked atrophic rhinitis in all animals which principally involved the anterior half of the nasal cavity and were characterized by purulent exudate in the nasal meatuses, chronic, active inflammation that was often ulcerative, necrosis and loss of the cartilagenous nasal septum, loss of boney turbinates, and squamous metaplasia of nasal epithelium
- Denudation of the mucosa occasionally resulted in exposure of conchal bone
- Resorption of facial bone was sometimes detected in areas of sever inflammation - Neuropathological findings:
- not specified
- Histopathological findings: non-neoplastic:
- effects observed, treatment-related
- Description (incidence and severity):
- A short term (10-day) exposure of rats by inhalation resulted in necrotizing inflamation in the nasal cavity at 250 and 1000 ppm dose levels. Moderate to marked amounts of atrophic rhinitis occurred in rats exposed to 500 ppm for 120 days. Due to the abscence of effects after exposure to dose levels up to 100 ppm for 120 days, this is considered to be the NOAEC.
- Histopathological findings: neoplastic:
- not specified
Effect levels
- Dose descriptor:
- NOAEC
- Effect level:
- 100 ppm
- Based on:
- test mat.
- Sex:
- male/female
- Basis for effect level:
- histopathology: non-neoplastic
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
- Conclusions:
- A NOAEC of 100 ppm was derived for the test item after repeated inhalative expsoure of rats for 120 days.
- Executive summary:
Repeated inhalative exposures of Fischer 344 rats to the test item were performed for various doses and time points. A short term (10-day) exposure of rats by inhalation resulted in necrotizing inflamation in the nasal cavity at 250 and 1000 ppm dose levels. Moderate to marked amounts of atrophic rhinitis occurred in rats exposed to 500 ppm for 120 days. Due to the abscence of effects after exposure to dose levels up to 100 ppm for 120 days, this is considered to be the NOAEC.
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