Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Short-term toxicity to aquatic invertebrates

Currently viewing:

Administrative data

Link to relevant study record(s)

Description of key information

With high probability acutely not harmful to aquatic invertebrates

Key value for chemical safety assessment

Fresh water invertebrates

Fresh water invertebrates
Dose descriptor:
Effect concentration:
108.82 mg/L

Additional information

The acute toxicity of MIPA (CAS 78-96-6) to aquatic invertebrates was determined in a static freshwater test conducted according to Directive 79/831/EEC, Annex V, Part C, using Daphnia magna as test species (BASF AG, 1992). The reported 48h EC50 of 108.8 mg/L indicates the test substance to be with high probability acutely not harmful to daphnids. The test substance solutions were not neutralized.


The study was conducted without analytical monitoring. However, it is assumed that the test concentrations remained stable over the exposure period based on a high water solubility (miscible at any ratio; see IUCLID ch. 4.8), a low vapour pressure (0.63 hPa at 25 °C, see IUCLID ch. 4.6) a low Henry's Law constant (4.95E-05 Pa m³/mol, HENRYWIN v3.20, BASF SE, 2017) and a low adsorption potential (log Kow = -0.93, BASF AG, 1987; log Koc = 1.53, according to Franco&Trapp, BASF SE, 2021). The stability over the exposure period was additionally confirmed by an available acute toxicity study on fish conducted with analytical monitoring and a recovery rate of 96% (Brooke, 1984).