Tris(2-butoxyethyl) phosphate

Exposure related observations in humans: other data

Administrative data

Endpoint:

exposure-related observations in humans: other data

Type of information:

experimental study

Adequacy of study:

supporting study

Reliability:

2 (reliable with restrictions)

Data source

Reference

Reference 1

Reference Type:

publication

Title:

Unnamed

Year:

1983

Reference 2

Reference Type:

publication

Title:

Unnamed

Year:

1986

Reference 3

Reference Type:

publication

Title:

Triaryl/alkyl phosphate residues in human adipose tissue autopsy samples from six Ontario municipalities

Author:

Lebel GL, Williams DT, Berard D

Year:

1989

Bibliographic source:

Bull. Environ. Contam. Toxicol., 43: 225-230.

Materials and methods

Type of study / information:

Concentration in adipose tissue

Endpoint addressed:

basic toxicokinetics

Test guideline

Qualifier:

no guideline required

Principles of method if other than guideline:

Post-mortem extraction of adipose tissue, with analytical analysis for TBEP concentration.

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

Tris(2-butoxyethyl) phosphate

EC Number:

201-122-9

EC Name:

Tris(2-butoxyethyl) phosphate

Cas Number:

78-51-3

Molecular formula:

C18H39O7P

IUPAC Name:

tris(2-butoxyethyl) phosphate

Method

Exposure assessment:

measured

Results and discussion

Results:

Concentration of TBEP ranged from 25 to 483 ng/g adipose tissue (individual values).
1983: TBEP mean concentration: 4.0 - 26.8 ng/g (4/16 samples)
1986: TBEP found in 21/68 male and 20/47 female samples
1989: TBEP overall mean concentration (41 samples): 11.3 ng/g (male=6.3; female=16.6 ng/g).
Ottawa: mean 15.8 ng/g (male+female); 28.6 ng/g (female); 7.9 ng/g (male)
Kingston: mean 6.6 ng/g (male+female); 8.7 ng/g (female); 3.6 ng/g (male)

Any other information on results incl. tables

TBEP was only detected in 3/6Ontario municipalities.

 

Table 1: Mean and range concentrations of TBEP (ng/g) in humans from Ontario.

 

Site	Sex	No	Mean	Range	Frequency
London	M	8	ND	ND	ND
London	F	8	25	ND	1/8
Toronto	M	4	425	400-483	4/4
Toronto	F	3	357	320-424	3/3
Toronto	M+F	7	396	320-483	7/7
Cornwall	M	8	165	ND-202	3/8
Cornwall	F	5	198	ND	1/5
Cornwall	M+F	13	173	ND-202	4/13

In Lebel & Williams (1983) 4 of 16 human adipose tissue samples were found to contain TBEP at levels of between 4.0 and 26.8 µg/kg.

 

In a later similar study (Lebel & Williams, 1986) of 115 samples obtained at autopsy from Kingston (58) and Ottawa (57), TBEP was found in 21/68 male samples and 20/47 female samples.

 

Table 2: Mean concentrations of TBEP in humans from Ottawa.

 

Site	Sex	Mean	Range (ng/g)
Kingston	M	3.6	0.7-12.9
Kingston	F	8.7	1.5-26.8
Kingston	M+F	6.6	0.7-26.8
Ottawa	M	7.9	1.0-21.7
Ottawa	F	28.6	0.9-142.2
Ottawa	M+F	15.8	0.9-142.2

 

The mean concentrations of TBEP in Ottawa were 2.5 -times those found in the Kingston samples. In both cities the TBEP level in females was 2-3-times that of the male samples.

The mean TBEP concentration in the 41 samples was 11.3 micrograms/kg (male=6.3; female=16.6 micrograms/kg).

Applicant's summary and conclusion

Conclusions:

Absorbed TBEP is distributed through the body and is present at low concentrations in adipose tissue.