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Diss Factsheets
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EC number: 203-375-0 | CAS number: 106-22-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://poisoncentres.echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Sensitisation data (human)
Administrative data
- Endpoint:
- sensitisation data (humans)
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable publication which meets basic scientific principles
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Sensitization to 26 fragrances to be labelled according to current European regulation - Results of the IVDK and review of the literature
- Author:
- Schnuch et al.
- Year:
- 2 007
- Bibliographic source:
- Contact Dermatitis 2007: 57: 1–10
Materials and methods
- Type of sensitisation studied:
- skin
- Study type:
- survey
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: recommendations of the International Contact Dermatitis Research Group (12) and the German Contact Dermatitis Research Group (DKG)
- Deviations:
- not specified
- GLP compliance:
- no
Test material
- Reference substance name:
- Citronellol
- EC Number:
- 203-375-0
- EC Name:
- Citronellol
- Cas Number:
- 106-22-9
- Molecular formula:
- C10H20O
- IUPAC Name:
- 3,7-dimethyloct-6-en-1-ol
Constituent 1
Method
- Type of population:
- other: occupational and general
- Subjects:
- - Number of subjects exposed: 2003
- Clinical history:
- - History of allergy or casuistics for study subject or populations: a standardized history (including age, sex, atopic diseases, current and former occupation(s), presumptive causal exposures), along with final diagnoses and site(s) of dermatitis are assessed and documented
- Controls:
- hydroxymethylpentylcyclohexene carboxaldehyde
- Route of administration:
- dermal
- Details on study design:
- TYPE OF TEST(S) USED: patch test (epicutaneous test)
ADMINISTRATION
- Testing/scoring schedule: testing for 24 or 48 h; readings until at least 72 h
EXAMINATIONS
- Grading/Scoring system: neg, ?, +, ++, +++, irritant, follicular
- Statistical analysis: Frequencies of sensitization (as % of patients tested) were calculated both as crude proportions and proportions standardized for sex and age. Subgroups of patients defined by sensitization to an index allergen were analysed for concomitant reactions (crude proportions). The reaction index (RI), relating the number of allergic reactions to the number of doubtful or irritant reactions, ranging from RI = -1 (all reactions nonallergic) to RI = + (all reactions being allergic), and the positivity ratio (PR), as the proportion (%) of þ reactions out of the total number of allergic reactions, were calculated as parameters to assess the patch test preparation. A low RI (e.g. -0.8) together with a high PR (e.g. 100%) is indicative of a ‘problematic patch test preparation, where a number of the ‘+’ reactions may be suspected to be falsely positive.
Results and discussion
- Results of examinations:
- SYMPTOMS
- Frequency: 0.5%
NO. OF PERSONS WITH/OUT REACTIONS COMPARED TO STUDY POPULATION
- Number of subjects with positive reactions: 9/2003
- Number of subjects with irritating reactions: 6/2003
Any other information on results incl. tables
Results:
Citronellol 1% | ||
Frequencies of sensitization | n | 2003 |
n pos | 9 | |
% pos | 0.5 | |
% pos std | 0.4 | |
95% CI | 0.1-0.8 | |
Reaction pattern | irr/? | 6 |
f | 1 | |
+ | 8 | |
++ | 1 | |
+++ | 0 | |
RI | 0.1 | |
PR | 88.9 |
Applicant's summary and conclusion
- Conclusions:
- Authores found Citronellol to be "clearly allergenic but less important in terms of sensitization frequency"
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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