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EC number: 203-375-0 | CAS number: 106-22-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
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- Endpoint summary
- Stability
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- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable, well documented study report. Test procedure according to national standards
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 979
- Report date:
- 1979
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Qualifier:
- according to guideline
- Guideline:
- other: FEDERAL REGISTER 38, NO. 187, PARA. 1500.42, 5. 27029; 27.09.73
- Principles of method if other than guideline:
- Method: Draize Test
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Citronellol
- EC Number:
- 203-375-0
- EC Name:
- Citronellol
- Cas Number:
- 106-22-9
- Molecular formula:
- C10H20O
- IUPAC Name:
- 3,7-dimethyloct-6-en-1-ol
- Details on test material:
- - Name of test material (as cited in study report): Citronellol
- Substance No.: 78/741
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- Vienna White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Sex: female
- Weight at study initiation: mean 2.57 kg (2.33 - 3.15 kg)
- Diet: SSNIFF sold by Intermast
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: left eye untreated, serves as control
- Amount / concentration applied:
- 0.1 ml
- Duration of treatment / exposure:
- application into the conjunctival sac of the lower right eyelid
- Observation period (in vivo):
- 8 days
- Number of animals or in vitro replicates:
- 6
- Details on study design:
- SCORING SYSTEM:
turgor/swelling of conjunctiva or opacity of cornea:
0 = nonexistant
1 = slight
2 = distinct
3 = intense
4 = severe
affected area of cornea:
1 = 0 < A < 1/4
2 = 1/4 <= A < 1/2
3 = 1/2 <= A < 3/4
4 = 3/4 <= A
redness of conjunctiva:
0 = regular
1 = slightly increased
2 = distinct
3 = intense
secretion:
0 = regular
1 = slightly increased
2 = distinctly increased
3 = highly increased
iris:
1 = ciliary injection
2 = iritia
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 24/48/72 hours
- Score:
- 30.5
- Max. score:
- 39
- Reversibility:
- not fully reversible within: 8 days
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- other: 24/48/72 hours
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 8 days
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- other: 24/48/72 hours
- Score:
- 0.28
- Max. score:
- 2
- Reversibility:
- fully reversible within: 8 days
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- other: 24/48/72 hours
- Score:
- 1.72
- Max. score:
- 3
- Reversibility:
- not fully reversible within: 8 days
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- other: 24/48/72 hours
- Score:
- 1.44
- Max. score:
- 4
- Reversibility:
- fully reversible within: 8 days
- Other effects:
- - scars in all animals
- suppuration in one animal
- pupil contraction in one animal
Any other information on results incl. tables
Results:
cornea | iris | conjunctiva | calculated irritation scores | ||||||||||
time | animal | opacity | area | redness | turgor/swelling | secretion | other | cornea | iris | conjunctiva | total | mean | |
24 h | 1 | 1 | 4 | 0 | 2 | 2 | 2 | scar | 20 | 0 | 12 | 32 | 33,67 |
2 | 1 | 4 | 0 | 2 | 2 | 2 | scar | 20 | 0 | 12 | 32 | ||
3 | 1 | 4 | 1 | 2 | 2 | 2 | scar | 20 | 5 | 12 | 37 | ||
4 | 1 | 4 | 0 | 2 | 2 | 2 | scar | 20 | 0 | 12 | 32 | ||
5 | 1 | 4 | 1 | 2 | 2 | 2 | scar | 20 | 5 | 12 | 37 | ||
6 | 1 | 4 | 0 | 2 | 2 | 2 | scar | 20 | 0 | 12 | 32 | ||
48 h | 1 | 1 | 4 | 0 | 1 | 1 | 1 | scar | 20 | 0 | 6 | 26 | 29,00 |
2 | 1 | 4 | 0 | 2 | 2 | 2 | scar | 20 | 0 | 12 | 32 | ||
3 | 1 | 4 | 1 | 2 | 2 | 3 | scar/suppuration | 20 | 5 | 14 | 39 | ||
4 | 1 | 4 | 0 | 2 | 1 | 1 | scar | 20 | 0 | 8 | 28 | ||
5 | 1 | 3 | 0 | 1 | 1 | 1 | scar | 15 | 0 | 6 | 21 | ||
6 | 1 | 4 | 0 | 2 | 1 | 1 | scar/pupil contraction | 20 | 0 | 8 | 28 | ||
72 h | 1 | 1 | 4 | 0 | 1 | 1 | 1 | scar | 20 | 0 | 6 | 26 | 28,83 |
2 | 1 | 4 | 1 | 2 | 1 | 2 | scar | 20 | 5 | 10 | 35 | ||
3 | 1 | 4 | 1 | 2 | 2 | 3 | scar/suppuration | 20 | 5 | 14 | 39 | ||
4 | 1 | 4 | 0 | 1 | 0 | 1 | scar | 20 | 0 | 4 | 24 | ||
5 | 1 | 3 | 0 | 1 | 1 | 1 | scar | 15 | 0 | 6 | 21 | ||
6 | 1 | 4 | 0 | 2 | 1 | 1 | scar/pupil contraction | 20 | 0 | 8 | 28 | ||
8 d | 1 | 0 | 0 | 0 | 0 | 0 | 0 | scar | 0 | 0 | 0 | 0 | 5,17 |
2 | 1 | 1 | 0 | 2 | 0 | 1 | scar | 5 | 0 | 6 | 11 | ||
3 | 0 | 0 | 0 | 1 | 0 | 1 | scar | 0 | 0 | 4 | 4 | ||
4 | 1 | 1 | 0 | 1 | 0 | 0 | scar | 5 | 0 | 2 | 7 | ||
5 | 1 | 1 | 0 | 1 | 0 | 0 | scar | 5 | 0 | 2 | 7 | ||
6 | 0 | 0 | 0 | 1 | 0 | 0 | scar | 0 | 0 | 2 | 2 | ||
Mean 24-72 h | 1 | 1.0 | 4.0 | 0.0 | 1.3 | 1.3 | 1.3 | 20.0 | 0.0 | 8.0 | 28.0 | ||
2 | 1.0 | 4.0 | 0.3 | 2.0 | 1.7 | 2.0 | 20.0 | 1.7 | 11.3 | 33.0 | |||
3 | 1.0 | 4.0 | 1.0 | 2.0 | 2.0 | 2.7 | 20.0 | 5.0 | 13.3 | 38.3 | |||
4 | 1.0 | 4.0 | 0.0 | 1.7 | 1.0 | 1.3 | 20.0 | 0.0 | 8.0 | 28.0 | |||
5 | 1.0 | 3.3 | 0.3 | 1.3 | 1.3 | 1.3 | 16.7 | 1.7 | 8.0 | 26.3 | |||
6 | 1.0 | 4.0 | 0.0 | 2.0 | 1.3 | 1.3 | 20.0 | 0.0 | 9.3 | 29.3 | |||
Mean 24-72 h | 1 | 3.89 | 0.28 | 1.72 | 1.44 | 1.67 | 19.4 | 1.4 | 9.7 | 30.5 |
24h after application of 0,1 ml of test substance:
slight opacity of complete cornea and in 2/6 cases ciliary injections;
all animals: distinct redness and turgor/swelling of conjunctiva, increased secretion of tears and scarred retractions at the eyelid
72h:
redness and turgor of conjunctiva and secretion in regression
8d:
3/6 animals show very light opacity of small areas of cornea,
5/6 show slight redness of conjunctiva,
2/6 show slightly increased secretion of tears,
1/6 shows temporary suppuration,
1/6 shows temporary contraction of the pupil;
all animals: irreversible scarred alterations of the eyelidprimary irritation score: 31 -> moderately irritating
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Not irritating acc. to EU criteria, but irritating acc. GHS criteria due to iris-scores >= 1.
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