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EC number: 245-366-4 | CAS number: 22984-54-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://poisoncentres.echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_classification-and-labelling-and-pbt-assessment.png)
PBT assessment
Administrative data
PBT assessment: overall result
- Name:
- butan-2-one-O,O',O''-(methylsilyldyne) trioxime
- Type of composition:
- legal entity composition of the substance
- State / form:
- liquid
- >= 93.1 - <= 97.9 % (w/w)
- Reference substance:
- butan-2-one-O,O',O''-(methylsilyldyne) trioxime
- Reference substance:
- butan-2-one-O,O',O''-(methylsilyldyne) trioxime
- This impurity is considered relevant for the classification and labelling of the substance
- PBT status:
- the substance is not PBT / vPvB
- Justification:
Persistence assessment:
Biodegradation in water: screening test: The substance is not ready biodegradable.
Hydrolysis: The substance is hydrolytically unstable in water. The half-life is expected to be < 1 hour at 25 ºC and therefore the substance is not persistent.
Conclusion on P / vP properties: The substance is not fulfilling the criteria for Persistence (P).
Bioaccumulation assessment:
The substance undergoes rapid hydrolysis in aqueous to butanone oxime and the corresponding methylsilanetriol. According to the bioaccumulation test in carp fish performed by MITI, butanone oxime has a low bioaccumulation potential (BFC= (0.5)-(0.6) at a concentration of 2 ppm, and <2.5 -(5.8) at a concentration of 0.2 ppm). At the same time, silanetriols undergo continuous condensation reactions to produce higher molecular weight siloxanes which are considered biologically unavailable.
It should be also taken into accoun that the estimated log octanol-water partition coefficients (Log Kow) for the degradation products 2 -butanone oxime and methylsilanetriol were 1.69 and -2.36 (EPI-Suite, KOWWIN v1.68). Since being the log Pow <3, they are expected to be of low bioaccumulation potential.
Based on the available information, the test item is determined to have low bioconcentration potential based on the properties of its degradation products.
Conclusion on B / vB properties: The substance is not fulfilling the criteria for Bioaccumulation (B).
Toxicity assessment:
- Long-term toxicity to fish: LC50 (14d) > 115.34 mg/L (based on mortality) and NOEC (14d) = 57.67.
- Long-term toxicity to aquatic invertebrates: LC50 (21d) > 115.34 mg/L (based on parental mortality), EC50 (21d) > 115.34 mg/L (based on reproduction) and NOEC (21d) >= 115.34 mg/L (based on reproduction).
- Toxicity to aquatic algae: NOEC (72h) = 3.00 mg/L (basis for effect: growth rate).
Moreover, regarding the acute aquatic toxicity:
- Short-term toxicity to fish: LC50 (96h) = 972.34 mg/L (based on mortality).
- Short-term toxicity to aquatic invertebrates: EC50 (48h) = 231.84 mg/L (based on mobility).
- Toxicity to aquatic algae: EC50 (72h) = 18.45 mg/L (based on growth rate).
The substance is not classified as CMR.
The substance is classified as STOT Rep. Exp. 2 (target organ: red blood cells) in accordance with CLP Regulation (EC) No 1272/2008, since significant toxic effects were observed in a 90-day repeated-dose study (oral) conducted in experimental animals within value ranges 10 -100 mg/kg bw/day.
Conclusion on T properties: The substance is determined to be T.
CONCLUSION:
2-Butanone, O,O',O'' -(methylsilylidyne)trioxime is not a PBT or vPvB substance.
Reference
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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