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Diss Factsheets
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EC number: 245-366-4 | CAS number: 22984-54-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://poisoncentres.echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_ecotoxicological-information.png)
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
- Endpoint:
- activated sludge respiration inhibition testing
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Justification for type of information:
- REPORTING FORMAT FOR THE ANALOGUE APPROACH
The analogue MAC3 component of the reaction mass Wasox-MMAC2, has a molecular structure similar to butan-2-one O,O',O''-(methylsilanetriyl)oxime and therefore, they also have comparable values for the relevant molecular properties for toxicity to microorganisms.
See attached reporting format. - Reason / purpose for cross-reference:
- read-across source
- Key result
- Duration:
- 3 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 403.93 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Remarks:
- (analogue substance)
- Basis for effect:
- inhibition of total respiration
- Remarks:
- respiration rate
- Remarks on result:
- other: (Based on read-across approach on an analogue)
- Details on results:
- Based on the experimental results on analogue substance Wasox-MMAC2 (EC50-3h > 300 mg/L for activated sludge of a predominantly domestic sewage), the read-across approach was applied and the EC50 (3h) for butan-2-one O,O',O''-(methylsilanetriyl)oxime was calculated to be > 403.93 mg/L.
- Validity criteria fulfilled:
- not applicable
- Conclusions:
- Based on read-across approach from experimental data on analogue Wasox-VMAC2, the 3h-EC50 for butan-2-one O,O',O''-(methylsilanetriyl)oxime was calculated to be > 403.93 mg/L.
- Executive summary:
An Activated Sludge, Respiration Inhibition Test was performed on analogue Wasox-MMAC2 according to the OECD Guideline 209 using activated sludge from a sewage treatment plant treating predominantly domestic sewage. The 3h-EC50 was determined to be > 300 mg/L, basis for effect: respiration rate. Based on these results, the read-across approach was applied and the 3h-EC50 for butan-2-one O,O',O''-(methylsilanetriyl)oxime was calculated to be > 403.93 mg/L.
- Endpoint:
- activated sludge respiration inhibition testing
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Justification for type of information:
- REPORTING FORMAT FOR THE ANALOGUE APPROACH
The analogue VAC3 component of the reaction mass Wasox-VMAC2, has a molecular structure similar to butan-2-one O,O',O''-(methylsilanetriyl)oxime and therefore, they also have comparable values for the relevant molecular properties for toxicity to microorganisms.
See attached reporting format. - Reason / purpose for cross-reference:
- read-across source
- Key result
- Duration:
- 3 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 390.45 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Remarks:
- (analogue substance)
- Basis for effect:
- inhibition of total respiration
- Remarks:
- respiration rate
- Remarks on result:
- other: (Based on read-across approach from an analogue)
- Details on results:
- Based on the experimental results on analogue substance Wasox-VMAC2 (EC50-3h > 300 mg/L) for activated sludge of a predominantly domestic sewage), the read-across approach was applied and the EC50 (3h) for EAC3 was calculated to be > 390.45 mg/L.
- Validity criteria fulfilled:
- not applicable
- Conclusions:
- Based on read-across approach from experimental data on analogue Wasox-VMAC2, the 3h-EC50 for butan-2-one O,O',O''-(methylsilanetriyl)oxime was calculated to be > 390.45 mg/L.
- Executive summary:
An Activated Sludge, Respiration Inhibition Test was performed on analogue Wasox-VMAC2 according to the OECD Guideline 209 using activated sludge from a sewage treatment plant treating predominantly domestic sewage. The 3h-EC50 was determined to be > 300 mg/L, basis for effect: respiration rate. Based on these results, the read-across approach was applied and the 3h-EC50 for butan-2-one O,O',O''-(methylsilanetriyl)oxime was calculated to be > 390.45 mg/L.
- Endpoint:
- toxicity to microorganisms, other
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Justification for type of information:
- REPORTING FORMAT FOR THE ANALOGUE APPROACH
See attached reporting format. - Reason / purpose for cross-reference:
- read-across source
- Key result
- Dose descriptor:
- other: Toxicity
- Effect conc.:
- >= 726.66 mg/L
- Remarks on result:
- other: (Based on read-across approach from an analogue)
- Validity criteria fulfilled:
- not applicable
- Conclusions:
- Based on the read-across approach from analogue substance butanone oxime, butan-2-one O,O',O''-(methylsilanetriyl)oxime was determined to be toxic to Pseudomonas sp. at 726.66 mg/L.
- Executive summary:
Based on the read-across approach from analogue substance butanone oxime, butan-2-one O,O',O''-(methylsilanetriyl)oxime
was determined to be toxic to Pseudomonas sp. at 726.66 mg/L.
- Endpoint:
- toxicity to microorganisms, other
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Justification for type of information:
- REPORTING FORMAT FOR THE ANALOGUE APPROACH
See attached reporting format. - Reason / purpose for cross-reference:
- read-across source
- Key result
- Duration:
- 5 min
- Dose descriptor:
- other: EC50
- Effect conc.:
- 1 101.52 mg/L
- Remarks on result:
- other: (Based on read-across approach from an analogue)
- Validity criteria fulfilled:
- not applicable
- Conclusions:
- Based on the read-across approach form experimental results on analogue butanone oxime, the 5 min-EC50 for butan-2-one O,O',O''-(methylsilanetriyl)oxime in Photobacterium phosphoreum was determined to be 1101.52 mg/L.
- Executive summary:
Based on the experimental results on analogue substance butanone oxime where the 5 min-EC50 for Photobacterium phosphoreum was determined to be 955 mg/L, the read-across approach was applied and the 5 min-EC50 for butan-2-one O,O',O''-(methylsilanetriyl)oxime was determined to be 1101.52 mg/L.
- Endpoint:
- toxicity to microorganisms, other
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Justification for type of information:
- REPORTING FORMAT FOR THE ANALOGUE APPROACH
The analogue methyltriacetoxysilane has a molecular structure similar to butan-2-one O,O',O''-(methylsilanetriyl)oxime and therefore, they also have comparable values for the relevant molecular properties for toxicity to microorganisms.
See attached reporting format. - Reason / purpose for cross-reference:
- read-across source
- Key result
- Duration:
- 28 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 136.87 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Remarks:
- (analogue substance)
- Basis for effect:
- other: Biodegradation
- Remarks on result:
- other: (Based on read-across approach from an analogue)
- Validity criteria fulfilled:
- not applicable
- Conclusions:
- Based on the experimental results on analogue substance methyltriacetoxysilane, the read-across approach was applied and NOEC (28 d) for butan-2-one O,O',O''-(methylsilanetriyl)oxime was calculated to be 136.87 mg/L.
- Executive summary:
A ready biodegradability manometic respirometry test was performed according to OECD Guideline 301 F on analogue methyltriacetoxysilane and 28 day-NOEC was determined to be 100 mg/L since the substance was readily biodegradable (79.5% of biodegradation at 28 days) and did not inhibit the degradation of the toxicity test (83.9% of biodegradation after 28 days) up to 100 mg/L under aerobic conditions. Based on this results, the read-across approach was applied and 28 day-NOEC for butan-2-one O,O',O''-(methylsilanetriyl)oxime was calculated to be 136.87 mg/L under test conditions.
Referenceopen allclose all
Description of key information
Weight of evidence: Read-across from experimental results on butanone oxime: butan-2-one O,O',O''-(methylsilanetriyl)oxime was determined to be toxic to Pseudomonas sp.at 726.66 mg/L.
Weight of evidence: Read-across from experimental results on butanone oxime the 5 min-EC50 for butan-2-one O,O',O''-(methylsilanetriyl)oxime was determined to be 1101.52 mg/L.
Weight of evidence: Read-across from experimental results on methyltriacetoxysilane: The 28 day-NOEC for butan-2-one O,O',O''-(methylsilanetriyl)oxime was calculated to be 136.87 mg/L under test conditions.
Weight of evidence: Read-across from experimental results on Wasox-VMAC2: the 3h-EC50 for butan-2-one O,O',O''-(methylsilanetriyl)oxime was calculated to be > 390.45 mg/L.
Weight of evidence: Read-across from experimental results on Wasox-MMAC2: the 3h-EC50 for butan-2-one O,O',O''-(methylsilanetriyl)oxime was calculated to be > 403.93 mg/L.
Key value for chemical safety assessment
- EC50 for microorganisms:
- 390.45 mg/L
- EC10 or NOEC for microorganisms:
- 136.87 mg/L
Additional information
The toxicity to microorganism is analized by the read-across approach from analogue substances:
- Read-across from experimental results on butanone oxime: By the read-across from butanone oxime, the toxicity to microorganism of the hydrolysis product of the test item is analysed and covered.
- Read-across from experimental results on analogue silanes: By the read-across from analogue silanes (methyltriacetoxysilane, Wasox-VMAC2 and Wasox-MMAC2), the toxicity to microorganism of the silane part of the substance is analysed and covered, since both test item Butan-2 -one O,O',O''-(methylsilanetriyl)oxime, like methyltriacetoxysilane, Wasox-VMAC2 and Wasox-MMAC2, undergo rapid hydrolsyis in aqueous to corresponding silanols and at the same time, these silanols undergo continuous condensation reactions.
Read-across from experimental results on butanone oxime:
Weight of evidence: Based on the read-across approach from analogue substance butanone oxime, butan-2-one O,O',O''-(methylsilanetriyl)oxime was determined to be toxic to Pseudomonas sp.at 726.66 mg/L.
Weight of evidence: Based on the experimental results on analogue substance butanone oxime where the 5 min-EC50 for Photobacterium phosphoreum was determined to be 955 mg/L, the read-across approach was applied and the 5 min-EC50 for butan-2-one O,O',O''-(methylsilanetriyl)oxime was determined to be 1101.52 mg/L.
Read-across from experimental results on analogue silanes:
Weight of evidence: Based on the experimental results obtained in a ready biodegradability test (OECD 301F) performed on analogue methyltriacetoxysilane (28 day-NOEC = 100 mg/L), the read-across approach was applied and the 28 day-NOEC for butan-2-one O,O',O''-(methylsilanetriyl)oxime was calculated to be 136.87 mg/L under test conditions.
Weight of evidence: Based on the experimental results obtained in an Activated Sludge, Respiration Inhibition Test (OECD 209) performed on analogue Wasox-VMAC2 (3h-EC50 > 300 mg/L, basis for effect: respiration rate), the read-across approach was applied and the 3h-EC50 for butan-2-one O,O',O''-(methylsilanetriyl)oxime was calculated to be > 390.45 mg/L.
Weight of evidence: Based on the experimental results obtained in an Activated Sludge, Respiration Inhibition Test (OECD 209) performed on analogue Wasox-MMAC2 (3h-EC50 > 300 mg/L, basis for effect: respiration rate), the read-across approach was applied and the 3h-EC50 for butan-2-one O,O',O''-(methylsilanetriyl)oxime was calculated to be > 403.93 mg/L.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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