Ethylene dimethacrylate

Dermal absorption

Administrative data

Endpoint:

dermal absorption

Type of information:

(Q)SAR

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Justification for type of information:

QSAR prediction

1. SOFTWARE
no software used

2. MODEL (incl. version number)
The prediction model used in this investigation for a set of methacrylate chemicals is based on an established model (Potts and Guy, 1992).

3. SMILES OR OTHER IDENTIFIERS USED AS INPUT FOR THE MODEL
not stated in report

4. SCIENTIFIC VALIDITY OF THE (Q)SAR MODEL
The “Relative Dermal Absorption” potential assigned to the predicted skin flux for methacrylate data is an arbitrary estimation of skin penetration potential, and is not a regulatory or OECD approved classification. It is based on several hundred chemicals tested in the same human skin model at the Central Toxicology Laboratory and Dermal Technology Laboratory. This database includes a wide variety of pharmaceutical, agrochemical and industrial chemicals tested over a 20 year period. The dermal absorption potential of a particular chemical substance is placed into one of six categories based on its skin permeability coefficient or its predicted (or actual) absorption rate

5. APPLICABILITY DOMAIN
not explicitely stated in the report

6. ADEQUACY OF THE RESULT
not explicitely stated in the report

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2013

Report date:

2013

Materials and methods

Principles of method if other than guideline:

Prediction of the skin penetration characteristics using the physicochemical properties used as a first level assessment of the ability of chemical to cross the human epidermis based on: Potts RO and Guy RH (1992). Predicting Skin Permeability. Pharm. Res. 9(5): 663-669

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

Ethylene dimethacrylate

EC Number:

202-617-2

EC Name:

Ethylene dimethacrylate

Cas Number:

97-90-5

Molecular formula:

C10H14O4

IUPAC Name:

2-[(2-methylprop-2-enoyl)oxy]ethyl 2-methylprop-2-enoate

Test animals

Species:

other: human skin QSAR

Details on test animals or test system and environmental conditions:

Prediction of the skin penetration characteristics using the physicochemical properties used as a first level assessment of the ability of chemical to cross the human epidermis based on: Potts RO and Guy RH (1992). Predicting Skin Permeability. Pharm. Res. 9(5): 663-669
Assumed skin temperature: 32 °C

Results and discussion

Any other information on results incl. tables

Chemical Class	Test Chemical / Compound Identity	Acronym	Molecular Weight	Log P	Predicted Flux (µg/cm^2/h)	Relative Dermal Absorption
Multi-func aliph/hydrophob DMA	Ethylene glycol dimethacrylate	EGDMA	198.22	2.4	6.109	Low

 

Applicant's summary and conclusion

Conclusions:

Based on the dermal penetration model for human skin the predicted skin penetration for EGDMA is low (6.109 µg/cm²/h).

Executive summary:

Based on the dermal penetration model for human skin the predicted skin penetration for EGDMA is low (6.109 µg/cm²/h).