Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
short-term repeated dose toxicity: other route
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Screening test. 5 animals only.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1956

Materials and methods

Principles of method if other than guideline:
Screening test
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Ethylene dimethacrylate
EC Number:
202-617-2
EC Name:
Ethylene dimethacrylate
Cas Number:
97-90-5
Molecular formula:
C10H14O4
IUPAC Name:
2-[(2-methylprop-2-enoyl)oxy]ethyl 2-methylprop-2-enoate
Test material form:
liquid

Test animals

Species:
rat
Strain:
not specified
Sex:
female

Administration / exposure

Route of administration:
subcutaneous
Vehicle:
polyethylene glycol
Duration of treatment / exposure:
4 days
Frequency of treatment:
daily
Doses / concentrations
Remarks:
Doses / Concentrations:
200 mg/kg
Control animals:
other: no data specified
Details on study design:
Post-exposure period: no data

Results and discussion

Target system / organ toxicity

Critical effects observed:
not specified

Any other information on results incl. tables

Scabs developed at the injection sites but there were no
systemic effects. A post mortem examination revealed nothing
abnormal. Histological examination of the major organs
revealed no signs of any pathological changes.

Applicant's summary and conclusion