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Diss Factsheets
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EC number: 906-170-0 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
Additional information
Assessment of absorption, distribution, metabolisation and excretion of the substance is based on the available experimental data.
Physico-chemical properties :
Water solubility: 4.0 to 40.5 g/L (at 20°C)
Partition coefficient in octanol/water: 0.6 to 1.4
Vapour pressure: 0.47 to 9.4 Pa (at 25°C)
Boiling point: 209.3°C
Absorption :
Inhalation:
The substance has a relatively low volatility for a solvent, as evidenced by the vapour pressures of its components and its elevated boiling point. The acute toxicity study by inhalation showed no mortality up to 11 mg/L, and no significant effects that were indicative of systemic effects resulting from absorption. Literature data on similar substances have shown a potential hydrolysis of methyl esters in the upper respiratory pathway, in particular by carboxylesterases that are present in the nasal epithelium. It is thus expected that the parent substance will be undergoing rapid enzymatic hydrolysis in the upper respiratory tract and will not be absorbed further as is.
Oral route:
There was no mortality or evidence of systemic toxicity in the acute oral toxicity study in rats at the dose of 5000 mg/kg bw. Apart from initial and sporadic decrease in body weight and body weight gain at the high dose levels, there were no signs of systemic toxicity in the 14-day dietary toxicity study in rats.
Dermal route:
There was no evidence of systemic toxicity in the acute dermal toxicity study in rats at the dose of 2000 mg/kg bw. There were neither any signs of toxicity or sensitisation effects after cutaneous exposure on the mouse ears in the LLNA assay.
Distribution :
It is likely that the parent substance is rapidly metabolised to methanol and mono- and/or diacids by ubiquitous non-specific esterases present in various organs, and therefore would not remain unchanged.
Inhalation exposure:
Following inhalation exposure of rats for up to 90 days in four different studies, using both individual methyl-esters or dibasic ester blend, no relevant sign of systemic toxicity allowing the identification of target organs were observed. The main findings consisted of degeneration/atrophy of the olfactory epithelium which can be considered as local effects of the exposure of the upper respiratory tract to the parent substance.
Other routes of exposure:
No target organs were identified following repeated administration to rats by oral (dietary) or dermal, although the duration of treatment was relatively limited (14 days) to enable appropriate assessment of subacute toxicity.
Metabolisation :
Carboxylesterases are widely distributed in the body of mammalian species and can hydrolyse various compounds, without being necessarily substrate-specific. It is expected that they would play a role in the metabolisation of the substance at various potential entry sites such as nasal epithelium, gastrointestinal tract and possibly skin.
No metabolic alteration was observed in repeated dose toxicity assays in organs such as liver or kidneys. The outcome of the in vitro bacterial reverse mutation assay was unaffected by the presence of metabolic activation or not. There was a significant difference in the response of human lymphocytes with or without metabolic activation, as clastogenic effects were only observed in the presence of liver microsomal fraction. However, this was not reproduced in vivo following inhalation exposure in a mouse bone marrow micronucleus assay, with intact metabolic capacities.
Excretion :
No data are available with regard to the excretion properties of the test substance.
Conclusion :
Available experimental data showed limited signs of absorption and distribution of the test substance or its metabolites following inhalation exposure as evidenced by local changes in the upper respiratory tract and the absence of other target organ or tissue. There were no systemic effects observed following dermal or oral exposure (acute or subacute exposures) that would provide evidence of significant absorption or distribution. The parent substance is expected to be hydrolysed by carboxylesterases at its entry sites.The available experimental data provided no indication on excretion.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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