Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 233-113-0 | CAS number: 10035-10-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Additional information
Acute toxicity to fish
Hydrogen bromide (HBr) forms hydrobromic acid in water. The toxic effect seen in aquatic organisms is from the acidity of the resulting solution, which is a function of the HBr concentration. Though there are minimal data on hydrogen bromide (HBr) available there are sufficient information available on the analogue substances hydrogen chloride (HCl) and phosphorus tribromide (which hydrolyses to phosphonic acid and HBr). (Read-across justifications in Section 8.6 Repeat dose toxicity.)
Evaluation of the analogous substance hydrogen chloride under the OECD ICCA HPV Programme (2003) stated that it was not considered useful to calculate a PNEC for hydrochloric acid because factors such as the buffer capacity, the natural pH and the fluctuation of the pH are very specific for a certain ecosystem. There is a possibility that the emission of hydrochloric acid could locally decrease the pH in the aquatic environment. Normally, the pH of effluents is measured very frequently to maintain the water quality. In addition to that, water quality including the range of pH could be managed properly to prevent adverse effects on the aquatic environment based on the criteria of the pH in rivers and lakes. Therefore, a significant decrease of the pH of the receiving water is not expected. Generally the changes in pH of the receiving water should stay within the natural range of the pH, and for this reason, adverse effects on the aquatic environment are not expected due to anthropogenic or naturally occurring hydrochloric acid. Hydrobromic acid will react in the same manner as hydrochloric acid, so the evaluation is equally valid for hydrobromic acid. HBr in water forms hydrobromic acid which dissociates to ions (H+ and Br-).
Toxicity data for the bromide ion is available in other submissions so adequate information for environmental classification and labelling of the dissociation products of hydrobromic acid is available.
Mattie, D.R., et al. (1996a) reported an experimental 96 hour LC50 for PBr3in fathead minnows (Pimephales promelas) is 75 mg/L (95% CL 50 to 100 mg/L). This is equivalent to 65.04 mg/L HBr (95% CL 45.8 to 91.6 mg/L). No observed effect concentration in the study was 25 mg/L PBr3(equivalent to 22.9 mg/L HBr).
Acute toxicity to aquatic invertebrates
Thiebaud, H. (1998) reported an EC50(48h) Daphnia = 39 mg/L. In an acute toxicity test (inhibition of mobility), Daphnia magna were exposed to concentrations of hydrobromic acid ranging from 2.09 to 47.99 mg/L, forming a geometric progression with a factor of 1.7. Test concentrations were measured by ionic chromotography, and EC50 values were calculated for the 24 and 48 hour periods using measured initial concentrations and regression analysis using the Probit/log model. EC50-24 hours was calculated to be 39 mg/L hydrobromic acid with 95% confidence interval ranging from 26 to 100 mg/L. The EC50-48 hours was calculated to be 19 mg/L with 95% confidence interval ranging from 15 to 25 mg/L.
Mattie, D.R., et al. (1996b) reported an LC50 (48h) = 22.6 mg/L on the analogue substance PBr3
Acute toxicity to aquatic algae
Thiebaud, H. (1999) performed a growth inhibition test on freshwater algae. Pseudokirchneriella subcapitata exposed to 48 % hydrobromic acid in solution for a duration of 72 hours, following EU method C3, the concentration of test substance causing a 50% reduction in biomass or in growth rate were determined. EC50-72 hours for biomass was 56 mg/L (95% CL 27-100) and EC50 for growth rate at 72 hours was 130 mg/L (95% CL 84-7040) A no effect concentration for biomass could not be determined, but the NOEC for growth rate was 32 mg/L (95% CL not determined)
Toxicity to microorganisms
HBr forms hydrobromic acid in water. The toxic effect seen to aquatic organisms is from the acidity of the resulting solution, which is a function of the HBr concentration. Evaluation of the analogous substance hydrogen chloride under the OECD ICCA HPV Programme (2003) stated that it was not considered useful to calculate a PNEC for hydrochloric acid because factors such as the buffer capacity, the natural pH and the fluctuation of the pH are very specific for a certain ecosystem. There is a possibility that the emission of hydrochloric acid could locally decrease the pH in the aquatic environment. Normally, the pH of effluents is measured very frequently to maintain the water quality. In addition to that, water quality including the range of pH could be managed properly to prevent adverse effects on the aquatic environment based on the criteria of the pH in rivers and lakes. Therefore, a significant decrease of the pH of the receiving water is not expected. Generally the changes in pH of the receiving water should stay within the natural range of the pH, and for this reason, adverse effects on the aquatic environment are not expected due to anthropogenic or naturally occurring hydrochloric acid. Hydrobromic acid will react in the same manner as hydrochloric acid, so the evaluation is equally valid for hydrobromic acid. HBr in water forms hydrobromic acid which dissociates to ions (H+ and Br-).
Toxicity data for the bromide ion is available in other submissions so adequate information for environmental classification and labelling of the dissociation products of hydrobromic acid is available.
It is therefore not technically feasible to conduct aquatic toxicity studies on HBr and is scientifically unjustified as the hydrolysis reaction of HBr indicates that the substance would not be released to sewage treatment plants.
Long-term toxicity to aq organisms
HBr forms hydrobromic acid in water. The toxic effect seen to aquatic organisms is from the acidity of the resulting solution, which is a function of the HBr concentration. Evaluation of the analogous substance hydrogen chloride under the OECD ICCA HPV Programme (2003) stated that it was not considered useful to calculate a PNEC for hydrochloric acid because factors such as the buffer capacity, the natural pH and the fluctuation of the pH are very specific for a certain ecosystem. There is a possibility that the emission of hydrochloric acid could locally decrease the pH in the aquatic environment. Normally, the pH of effluents is measured very frequently to maintain the water quality. In addition to that, water quality including the range of pH could be managed properly to prevent adverse effects on the aquatic environment based on the criteria of the pH in rivers and lakes. Therefore, a significant decrease of the pH of the receiving water is not expected. Generally the changes in pH of the receiving water should stay within the natural range of the pH, and for this reason, adverse effects on the aquatic environment are not expected due to anthropogenic or naturally occurring hydrochloric acid. Hydrobromic acid will react in the same manner as hydrochloric acid, so the evaluation is equally valid for hydrobromic acid. HBr in water forms hydrobromic acid which dissociates to ions (H+ and Br-).
Toxicity data for the bromide ion is available in other submissions so adequate information for environmental classification and labelling of the dissociation products of hydrobromic acid is available.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.