Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 212-485-8 | CAS number: 822-06-0
PBT assessment
Administrative data
PBT assessment: overall result
- PBT status:
- the substance is not PBT / vPvB
- Justification:
Persistence Assessment
Hexamethylene disiocyanate (HDI) is not readily biodegradable with 42 % biodegradation in 28 days (Bayer AG, 2000). However, biodegradation is irrelevant as primary degradation step because of immediate hydrolysis takes place with a half-life of 0.23 hours. The hydrolysis products are mainly polyurea components and to a very low extent hexamethylene diamine. Polyurea is known to be inert and is probably due to its molecular size not bioavailable. Moreover, polyurea is considered insoluble in water and is characterised by limited mobility. However, a full weight-of-evidence approach as described in REACH Guidance Document R11 (2017) is not possible due to the limitations of the available hydrolysis studies. Therefore, based on the results of the ready and inherent biodegradation studies, HDI is classified as preliminary persistent according to screening criteria.
Bioaccumulation Assessment
Measured bioconcentration factors (BCF) for hexamethylene diisocyanate (HDI) are not available. Hexamethylene diisocyanate (HDI) hydrolyses rapidly in the presence of water with a half life of 0.23 hours. Therefore a risk estimation regarding the bioaccumulation potential of hexamethylene diisocyanate (HDI) on the basis of a log Kow, determined by QSAR, is misleading. A calculated theoretical log Kow value of 3.2 reflects the unreacted molecule without influence of water.
The hydrolysis product, hexamethylene diamine (HDA) is also not bioaccumulative. With a measured log Kow (OECD 107) of 0.02 (BASF 1978, not validated), a BCF of 3.2 was calculated with BCFWIN Program (v2.17)) (Currenta 2009f).
On the basis of these information it can not be expected that bioaccumulation of hexamethylene diisocyanate (HDI) occurs. Therefore the B and the vB criteria are not fulfilled.
T-criterion
There is one aquatic toxicity test for algae available which counts as a chronic test. The NOEC was 11.7 mg/l. Furthermore, the substance is not classified as carcinogenic, mutagenic or toxic for reproduction according to criteria of REACH Annex XIII. For these reasons, the substance does not meet the T-criterion.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
