Registration Dossier
Registration Dossier
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EC number: 212-485-8 | CAS number: 822-06-0
Additional toxicological data
Administrative data
- Endpoint:
- additional toxicological information
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: acceptable, well documented publication which meets basic scientific principles
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- The guinea pig model of diisocyanate sensitization - I. Immunological studies
- Author:
- Chen SE & Bernstein IL
- Year:
- 1 982
- Bibliographic source:
- J. Allergy Clin. Immunol. 70 (5): 383-392
- Reference Type:
- publication
- Title:
- The guinea pig model of diisocyanate sensitization - II. Physiologic studies
- Author:
- Bernstein IL et al.
- Year:
- 1 982
- Bibliographic source:
- J. Allergy Clin. Immunol. 70 (5): 393-398
Materials and methods
Test material
- Reference substance name:
- Hexamethylene diisocyanate
- EC Number:
- 212-485-8
- EC Name:
- Hexamethylene diisocyanate
- Cas Number:
- 822-06-0
- Molecular formula:
- C8H12N2O2
- IUPAC Name:
- 1,6-diisocyanatohexane
Constituent 1
Results and discussion
Any other information on results incl. tables
Intradermally immunized guinea pigs reacted positive in the test for passive cutaneous anaphylaxia and hapten specific antibodies were
detected. Also i.v. induction and challenge caused allergic lung reactions.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
