Registration Dossier
Registration Dossier
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EC number: 201-766-0 | CAS number: 87-69-4
Respiratory sensitisation
Administrative data
- Endpoint:
- respiratory sensitisation
- Remarks:
- other: medical monitoring
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The study has been assessed for the use in a category approach. According to the methodology and to the extent of available details, the study has been judged as reliable with restrictions.
Data source
Reference
- Reference Type:
- publication
- Title:
- Indagine su un gruppo di soggetti con esposizione professionale ad acido tartarico
- Author:
- Moscato et al.
- Year:
- 1 983
- Bibliographic source:
- ltal. Med. Lav. 1983; 5: 193-198.
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Evaluation of human workers occupationally-exposed to tartaric acid.
The study reports the results of un investigation carried out in a factory producing tartaric acid in order to evaluate the effects of occupational exposure to tartaric acid. A group of 74 subjects exposed to the acid and a group of 30 subjects not exposed, as a means of control, were submitted to unamnestic questionnaire. - GLP compliance:
- not specified
Test material
- Reference substance name:
- (+)-tartaric acid
- EC Number:
- 201-766-0
- EC Name:
- (+)-tartaric acid
- Cas Number:
- 87-69-4
- Molecular formula:
- C4H6O6
- IUPAC Name:
- (2R,3R)-2,3-dihydroxybutanedioic acid
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
- Details on test material:
- No further details on the test material identity are available.
Constituent 1
Test animals
- Species:
- human
- Strain:
- other: not applicable
- Sex:
- not specified
Test system
- Route of induction exposure:
- other:
- Route of challenge exposure:
- inhalation
- Vehicle:
- not specified
- Concentration:
- no data
- No. of animals per dose:
- Selection of the subjects:
- 74 workers
44 subjects belonging to risk group, assigned the production of tartaric acid.
30 subjects belonging to the control group (not exposed to tartaric acid)
- history evaluated for each subject: occupational, family, medical - Details on study design:
- no data
- Challenge controls:
- no data
- Positive control substance(s):
- not specified
- Negative control substance(s):
- other: not exposed subjects
Results and discussion
Applicant's summary and conclusion
- Interpretation of results:
- not sensitising
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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