Registration Dossier
Registration Dossier
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EC number: 234-190-3 | CAS number: 10588-01-9
Direct observations: clinical cases, poisoning incidents and other
Administrative data
- Endpoint:
- direct observations: clinical cases, poisoning incidents and other
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Quantification of exposure is not possible, however findings are consistent and the conclusion is clear
Data source
Reference
- Reference Type:
- other: review
- Title:
- European Union Risk Assessment Report: chromium trioxide, sodium chromate, sodium dichromate, ammonium dichromate and potassium dichromate
- Author:
- European Chemicals Bureau
- Year:
- 2 005
- Bibliographic source:
- 3rd. Priority List; Volume 53
Materials and methods
- Study type:
- other: studies and reports summarised in an EU review
- Endpoint addressed:
- eye irritation
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Review of published reports of accidental/occupational exposure
- GLP compliance:
- no
- Remarks:
- Not applicable
Test material
- Reference substance name:
- Chromium trioxide
- EC Number:
- 215-607-8
- EC Name:
- Chromium trioxide
- Cas Number:
- 1333-82-0
- Molecular formula:
- CrO3
- IUPAC Name:
- Trioxochromium
- Reference substance name:
- Sodium chromate
- EC Number:
- 231-889-5
- EC Name:
- Sodium chromate
- Cas Number:
- 7775-11-3
- Molecular formula:
- CrH2O4.2Na
- IUPAC Name:
- disodium dioxido(dioxo)chromium
- Reference substance name:
- Sodium dichromate
- EC Number:
- 234-190-3
- EC Name:
- Sodium dichromate
- Cas Number:
- 10588-01-9
- Molecular formula:
- Cr2Na2O7
- IUPAC Name:
- sodium dichromate
- Reference substance name:
- Potassium dichromate
- EC Number:
- 231-906-6
- EC Name:
- Potassium dichromate
- Cas Number:
- 7778-50-9
- Molecular formula:
- Cr2H2O7.2K
- IUPAC Name:
- potassium dichromate
- Details on test material:
- The EU RAR covers the folloiwng water soluble hexavalent chromium compounds:
chromium trioxide
sodium chromate
sodium dichromate
ammonium dichromate
potassium dichromate
Constituent 1
Constituent 2
Constituent 3
Constituent 4
Method
- Subjects:
- Various reports of occupational accidental exposure
- Route of exposure:
- ocular
- Reason of exposure:
- unintentional, occupational
- Exposure assessment:
- not specified
Results and discussion
- Clinical signs:
- Significant damage to the eye can occur upon accidental exposure to highly water-soluble Cr (VI) compounds.
Any other information on results incl. tables
Accidental splashing of highly water-soluble Cr(VI) compounds in solution into the eye has resulted in damage to the human eye. A number of case reports have detailed both inflammation of the cornea and conjunctivae and in more severe cases, corneal erosion and ulceration. The severity of response is increased by low pH or high temperature. Accidental eye contact with the corrosive aqueous chromium (VI) trioxide results in conjunctival congestion and necrosis and corneal oedema and opacity.
Applicant's summary and conclusion
- Conclusions:
- Accidental exposure to Cr (VI) compounds has the potential to cause irritation and damage to the eye.
- Executive summary:
The reports reviewed in the EU RAR show that accidental occupational exposure of the eye to Cr (VI) compounds can cause irritation and damage.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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