Sodium dichromate

Repeated dose toxicity: inhalation

Administrative data

Endpoint:

sub-chronic toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

supporting study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Well reported literature study, but with a non-standard design. Findings are consistent with those in other similar studies.

Data source

Reference

Reference Type:

publication

Title:

Effects of chromium compounds to the respiratory system. Part 5.

Author:

Adachi S

Year:

1987

Bibliographic source:

Jpn J Ind Health 1987 (29); 17-33

Materials and methods

Test guideline

Qualifier:

no guideline followed

Principles of method if other than guideline:

The study investigated toxicity to the respiratory tract follwoing repeated inhalation exposure to chromic acid mist for two 60 minute periods a week for 8-12 months.

GLP compliance:

not specified

Remarks:

Literature study

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Chromic acid

EC Number:

231-801-5

EC Name:

Chromic acid

Cas Number:

7738-94-5

Molecular formula:

CrH2O4

IUPAC Name:

dihydroxy(dioxo)chromium

Constituent 2

Reference substance name:

Chromium trioxide

EC Number:

215-607-8

EC Name:

Chromium trioxide

Cas Number:

1333-82-0

Molecular formula:

CrO3

IUPAC Name:

Trioxochromium

Details on test material:

Chromic acid (mist); aqueous chromium trioxide

Test animals

Species:

mouse

Strain:

C57BL

Sex:

female

Administration / exposure

Route of administration:

inhalation: aerosol

Type of inhalation exposure:

whole body

Vehicle:

other: unchanged (no vehicle)

Remarks on MMAD:

MMAD / GSD: Data are not reported, but other studies by the same authors report particles of inhalable size (predominantly <5 um)

Analytical verification of doses or concentrations:

not specified

Duration of treatment / exposure:

Mice were exposed for two periods of 60 minutes per week, for 8-12 months.

Frequency of treatment:

Mice were exposed for two periods of 60 minutes per week, for 8-12 months.

Doses / concentrations

Remarks:

Doses / Concentrations:
1.81 mg/m3
Basis:
analytical conc.

No. of animals per sex per dose:

Exposed animals were terminated at 8-12 months (23 animals, including 3 decedents) or 12-18 months (20 animals including 3 decedents). Twenty unexposed controls were terminated at 18 months.

Control animals:

yes, concurrent no treatment

Results and discussion

Effect levels

Dose descriptor:

LOAEC

Effect level:

1.81 mg/m³ air

Sex:

female

Basis for effect level:

other: Single exposure level: irritant and corrosive effects

Target system / organ toxicity

Critical effects observed:

not specified

Any other information on results incl. tables

Irritant and corrosive effects in the respiratory tract (perforated nasal septum, tracheal and bronchial epithelial hyperplasia, emphysema) occurred in treated animals.

Applicant's summary and conclusion

Conclusions:

Exposure to chromic acid mist at the exposure level equivalent to 1.81 mg Cr/m3 for 8-12 months was found to induce changes consisitent with irritation and corrosion in the respiratory tract of female mice.

Executive summary:

Female ICR mice were exposed to chromic acid mist at a concentration equivalent to 1.81 mg Cr/m3 for two 60 -minute periods a week for 8 -12 months. Exposure was found to induce changes consisitent with irritation and corrosion in the respiratory tract.