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EC number: 294-799-5 | CAS number: 91770-15-9 A complex combination of hydrocarbons obtained by subjecting a petroleum distillate to a sweetening process to convert mercaptans or to remove acidic impurities. It consists predominantly of hydrocarbons having carbon numbers predominantly in the range of C9 through C16 and boiling in the range of 130°C to 290°C (266°F to 554°F).
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://poisoncentres.echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: This study is classified as reliable with restrictions because it is an acceptable and well-documented study report.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 986
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: EPA Guidelines in FR Vol. 44, No. 145, pgs. 44054-44093
- GLP compliance:
- yes
Test material
- Reference substance name:
- 8008-20-6
- Cas Number:
- 8008-20-6
- IUPAC Name:
- 8008-20-6
- Reference substance name:
- Kerosine/heating oil
- IUPAC Name:
- Kerosine/heating oil
- Test material form:
- other: low viscosity liquid hydrocarbon
- Details on test material:
- Test substance:Kerosine/heating oil (F-76-01)
- Lot/batch No.: 2070
- Storage condition of test material: vented and continuously monitored for temperature. The test material was stored at 60-100°F
- Physical description: clear liquid
- Density: 0.8170 g/mL
- Purity: 100% hydrocarbons
Constituent 1
Constituent 2
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Alpine Rabbitry, Sandy, Utah
- Age at study initiation: 8-14 weeks old
- Weight at study initiation: 1.8-2.3 kg
- Housing: caged individually in stainless steel cages
- Diet (e.g. ad libitum): ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period: 16 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 66-74 degrees F
- Humidity (%): 29-53%
- Photoperiod (hrs dark / hrs light): 12/12
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- other: intact skin
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not specified
- Amount / concentration applied:
- undiluted
- Duration of treatment / exposure:
- 24 hour(s)
- Observation period:
- 24 and 72 hours and 4,5,6,7,8,9,10 days
- Number of animals:
- 6
- Details on study design:
- TEST SITE
- Area of exposure: 1" square
- Type of wrap if used: covered with 1" square gauze pads stabilized with a strip of hypoallergenic tape after which a dental dam was applied to the test sites and secured with 3" wide tape.
REMOVAL OF TEST SUBSTANCE
- Washing (if done): wiped
- Time after start of exposure: 24 hours
SCORING SYSTEM: Draize (1959).
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Remarks:
- intact skin
- Basis:
- mean
- Time point:
- 24 h
- Score:
- 3.13
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 10 days
- Remarks on result:
- other: erythema scores ranging from 2-4 in all except one animal who scored 1 at 24 hours
- Irritation parameter:
- erythema score
- Remarks:
- intact skin
- Basis:
- mean
- Time point:
- 48 h
- Remarks on result:
- not measured/tested
- Irritation parameter:
- erythema score
- Remarks:
- intact skin
- Basis:
- mean
- Time point:
- 72 h
- Score:
- 3.5
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 10 days
- Irritation parameter:
- edema score
- Remarks:
- intact skin
- Basis:
- mean
- Time point:
- 24 h
- Score:
- 2.42
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 10 days
- Remarks on result:
- other: scores ranged mostly from 2-4
- Irritation parameter:
- edema score
- Remarks:
- intact skin
- Basis:
- mean
- Time point:
- 48 h
- Remarks on result:
- not measured/tested
- Irritation parameter:
- edema score
- Remarks:
- intact skin
- Basis:
- mean
- Time point:
- 72 h
- Score:
- 1.92
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 10 days
Any other information on results incl. tables
Observation
for irritation was extended to 10 days. Although the degree of edema
declined throughout the observation period, the
degree of erythema and eschar did not decline so markedly. Scores for
the range of erythema and edema as well as the average irritation
scores and their ranges are summarised in the following table.
Obs. period |
Range of scores |
Irritation index |
||
|
Erythema |
Edema |
Mean |
Range |
24 hr |
1-4 |
0-4 |
5.6 |
1.0-7.5 |
72 hr |
2-4 |
1-3 |
5.4 |
3.8-6.2 |
4 day |
3-4 |
1-3 |
5.4 |
4.5-6.0 |
5 day |
2-4 |
0-2 |
4.9 |
4.0-6.0 |
6 day |
1-4 |
0-1 |
4.3 |
3.5-4.8 |
7 day |
1-4 |
0-1 |
4.0 |
3.2-4.8 |
8 day |
1-3 |
0-2 |
3.3 |
2.0-4.2 |
9 day |
1-3 |
0-1 |
3.2 |
2.2-4.0 |
10 day |
0-4 |
0-1 |
3.7 |
2.2-4.0 |
On the basis of these findings, the test material was described as
a moderate
dermal irritant.
Applicant's summary and conclusion
- Interpretation of results:
- irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The mean erythema and edema scores over 72 hours (i.e., average of 24 and 72 hour readings) were 3.46 and 2.33 for intact skin for each endpoint respectively. The test material was classified as irritating according to EU criteria.
- Executive summary:
In a primary dermal irritation study, 6 female New Zealand White rabbits were dermally exposed to undiluted Kerosine/heating oil (0.5mL per test site). Two of the test sites on each rabbit were intact skin. After exposure, the test site was covered with a gauze pad and the trunk of the rabbit was wrapped in an impervious covering. Twenty-four hours later the patches were removed and any residual material was wiped from the skin. Each of the test sites was evaluated for skin responses within 60 minutes of patch removal (24 hour reading), and again at 72 hours, then daily until 9 days post-application. The responses were scored using the Draize scale.
The mean erythema and edema scores over 72 hours (i.e., average of 24 and 72 hour readings) were 3.46 and 2.33 for intact skin for each endpoint respectively. The test material was classified as irritating according to EU criteria.
This study received a Klimisch score of 2 and is classified as reliable with restrictions because it is an acceptable and well-documented study report.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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