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Diss Factsheets
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EC number: 203-396-5 | CAS number: 106-42-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Endpoint summary
Administrative data
Description of key information
Additional information
Complete acute datasets are available for each of the xylene isomers. Based on the very similar physico-chemical properties of the isomers and the similarity of the results from the acute ecotoxicity studies, we believe that it is appropriate to combine the ecotoxicity data from the three isomers.
Data from chronic fish studies are available for p-xylene and mixed xylenes. Data from chronic invertebrate and algal studies are available for m- and p-xylene. Again, based on the very similar physico-chemical properties of the isomers and the similarity of the results from the chronic ecotoxicity studies, we believe that it is appropriate to combine all the available data. This results in a chronic dataset of two invertebrate studies, two fish studies, and a single algal study.
The screening criteria for toxicity in the PBT assessment is that a substance with an acute L(E)C50 <0.1 mg/L is considered to potentially meet the T criterion and an L(E)C50 <0.01 mg/L indicates a substance is definitely T. Chronic fish studies are available for p-xylene and mixed xylenes and acute and chronic ecotoxicity data are available from studies conducted with m, p and o-xylene. The most conservative results are: 96 hour LC50 for fish is 2.6 mg/L for p-xylene (Galassi et al. 1988), 24 hour EC50 for invertebrates of 1 mg/L for o-xylene (Galassi et al. 1988), 73 hour EC50 for algae of 4.36 mg/L for p-xylene (TNO, 2004), 35 day NOEC for fish of 0.714 mg/L for p-xylene (Noack, 2017), 7 day NOEC for invertebrates of 1.17 mg/L for m-xylene (Niederlehner et al. 1998) and 73 hour NOEC for algae of 0.44 mg/L for p-xylene (TNO 2004). All of the acute toxicity values are greater than the screening criteria and the chronic toxicity values are greater than the criteria in Annex XIII of the REACH regulations. Therefore, the xylene isomers are not considered to be T.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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