Registration Dossier
Registration Dossier
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EC number: 201-607-5 | CAS number: 85-44-9
Toxicity to birds
Administrative data
- Endpoint:
- toxicity to birds, other
- Remarks:
- embryotoxicity
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- significant methodological deficiencies
Data source
Reference
- Reference Type:
- publication
- Title:
- Toxicity of rubber chemicals towards three-day chicken embryos
- Author:
- Korhonen, A. et al.,
- Year:
- 1 983
- Bibliographic source:
- Scand. J. Work Environ. Health 9, 115-119
Materials and methods
- GLP compliance:
- no
Test material
- Reference substance name:
- Phthalic anhydride
- EC Number:
- 201-607-5
- EC Name:
- Phthalic anhydride
- Cas Number:
- 85-44-9
- Molecular formula:
- C8H4O3
- IUPAC Name:
- 1,3-dihydro-2-benzofuran-1,3-dione
Constituent 1
- Analytical monitoring:
- no
Test organisms
- Test organisms (species):
- other: White Leghorn chicken
Results and discussion
Effect levels
- Duration (if not single dose):
- 11 d
- Dose descriptor:
- other: ED50
- Effect level:
- 0.38 other: µmol/egg
- Further details on results:
- maximum percentage of malormed embryos: 20 %
Applicant's summary and conclusion
- Executive summary:
The toxicity of phthalic anhydride towards three-day chicken embryos was tested. An ED50 value of 0.38 µmol/egg was measured (Korhonen, 1983).
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