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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Basic toxicokinetics

Currently viewing:

Administrative data

Endpoint:
basic toxicokinetics in vitro / ex vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: scientifically acceptable and well documented

Data source

Reference
Reference Type:
publication
Title:
Kinetic study of the hydrolysis of phthalic anhydride and aryl hydrogen phthalates
Author:
Andrés GO, Granados AM, de Rossi RH
Year:
2001
Bibliographic source:
J. Org. Chem. 66, 7653-7657.

Materials and methods

Objective of study:
other: hydrolysis test
Principles of method if other than guideline:
The rate of hydrolysis of phthalic anhydride was determined at different pHs at 25°C in water/buffer containing a small amount of acetonitrile.
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Phthalic anhydride
EC Number:
201-607-5
EC Name:
Phthalic anhydride
Cas Number:
85-44-9
Molecular formula:
C8H4O3
IUPAC Name:
1,3-dihydro-2-benzofuran-1,3-dione
Radiolabelling:
no

Test animals

Species:
other: not applicable - in vitro test
Strain:
other: not applicable - in vitro test
Sex:
not specified

Administration / exposure

Route of administration:
other: not applicable - in vitro test
Vehicle:
other: aqueous solution with HCl or buffer + acetonitrile
Duration and frequency of treatment / exposure:
Not applicable - in vitro test
Doses / concentrations
Remarks:
Doses / Concentrations:
not applicable - in vitro test
No. of animals per sex per dose / concentration:
Not applicable - in vitro test
Control animals:
other: not applicable - in vitro test

Results and discussion

Preliminary studies:
no data

Toxicokinetic / pharmacokinetic studies

Details on absorption:
Not applicable- in vitro test
Details on distribution in tissues:
Not applicable - in vitro test
Details on excretion:
Not applicable - in vitro test
Toxicokinetic parametersopen allclose all
Toxicokinetic parameters:
half-life 2nd: not applicable - in vitro test
Toxicokinetic parameters:
half-life 1st: not applicable - in vitro test
Toxicokinetic parameters:
half-life 3rd: not applicable - in vitro test

Metabolite characterisation studies

Metabolites identified:
yes
Details on metabolites:
Phthalic anhydride hydrolyzes rapidly in the presence of water forming phthalic acid.

Any other information on results incl. tables

No remarks

Applicant's summary and conclusion

Executive summary:

The rate of hydrolysis of phthalic anhydride was determined at different pHs at 25°C in water/buffer containing a small amount of acetonitrile.

Phthalic anhydride hydrolyzes rapidly in the presence of water forming phthalic acid. Half-life for phthalic anhydride was 30.5 seconds at pH 7.24. At pH 6.8 the half-life of phthtalic anhydride in water was prolonged to 61 seconds.