Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 231-146-5 | CAS number: 7440-36-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://poisoncentres.echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Exposure related observations in humans: other data
Administrative data
- Endpoint:
- exposure-related observations in humans: other data
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study does not totally comply with the specific testing guideline, but reasonably are well-documented.
Data source
Reference
- Reference Type:
- publication
- Title:
- Genotoxic Risk and Oxidative DNA Damage in Workers Exposed to Antimony Trioxide.
- Author:
- Cavallo D., Iavicoli I., Setini A., Marinaccio A., Perniconi B., Carelli G. and Iavicoli S.
- Year:
- 2 002
- Bibliographic source:
- Environmental and Molecular Mutagenesis, 40: 184-189
Materials and methods
- Type of study / information:
- human data
- Endpoint addressed:
- genetic toxicity
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The genotoxicity of antimony trioxide in occupationally exposed workers was assessed by the sister chromatid exchange (SCE) and micronucleus (MN) tests and the enzyme (Fpg)-modified comet assay.
- GLP compliance:
- no
- Remarks:
- not applicable
Test material
- Reference substance name:
- Diantimony trioxide
- EC Number:
- 215-175-0
- EC Name:
- Diantimony trioxide
- Cas Number:
- 1309-64-4
- Molecular formula:
- Sb2O3
- IUPAC Name:
- dioxodistiboxane
- Test material form:
- not specified
Constituent 1
Method
- Ethical approval:
- other: The Ethical Committee of the "Universita Cattalica del Sacro Cuore (UCSC)" and the Scientific Committee of ISPESL approved the human study.
- Exposure assessment:
- measured
- Details on exposure:
- TYPE OF EXPOSURE MEASUREMENT: Area air sampling
Airborne antimony trioxide was collected with personal samplers (n=41). Air was sampled in conformity with ISO 7708. Sampling was scheduled
throughout the working week. Sample preparation for analysis involved microwave digestion of filters with 69-70%HNO3. The HNO3 was then
neutralized with ammonia and Sb2O3 was dissolved with aqueous tartaric acid (2g/l). Antimony was determined by atomic absorption spectrometry
(AAS).
Air sampling was not performed in the control group.
EXPOSURE LEVELS:
The mean air concentration of antimony, expressed as elemental antimony/m*3 of air inhaled was 0.12 +/- 0.11µg/m*3 for Group A
and 0.052 +/- 0.038µg/m*3 for Group B. The difference was statistically significant. (Student`s t-test, P=0.02). The mean concentration is lower than occupational limit values (generally 0.5 mg/m+3).
EXPOSURE PERIOD:
from Monday through Friday
- no other details on exposure are stated
Results and discussion
- Results:
- The mean SCE and MN did not differ significantly between the three groups (A, B and control), analysed by one-way ANOVA and Dunnett´s test.
In the high dose (Group A), 11 subjects had significant levels of oxidative damage versus 5.5 expected.
After adjustment of confounding factors the measure of risk for Group A subjects compared to controls was 14.2 (P=0.002).
No other significant findings could be seen. In this study the “high exposure group” is exposed to air concentrations that is almost equivalent to
ambient air concentrations and no monitoring of the non-exposed control workers were performed for comparison.
In addition, the workers are likely exposed to a series of chemicals which had not been identified.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
![ECHA](/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/echa_logo.png)