Registration Dossier
Registration Dossier
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EC number: 236-882-0 | CAS number: 13531-52-7
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1976 - 1977
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Meets generally accepted scientific standards, well documented and acceptable for assessment.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 977
- Report date:
- 1977
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Method: other: according to H.F. Smyth et al.: Am. Ind. Hyg. Ass. J. 23, 95-107, (1962)
- GLP compliance:
- no
- Remarks:
- study was performed prior to GLP
- Test type:
- other: Inhalation hazard test
- Limit test:
- no
Test material
- Reference substance name:
- N-(2-aminoethyl)-1,3-propanediamine
- EC Number:
- 236-882-0
- EC Name:
- N-(2-aminoethyl)-1,3-propanediamine
- Cas Number:
- 13531-52-7
- Molecular formula:
- C5H15N3
- IUPAC Name:
- N1-(2-Aminoethyl)-1,3-propanediamine
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 226 g (mean)
Administration / exposure
- Route of administration:
- inhalation: vapour
- Vehicle:
- other: unchanged (no vehicle)
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Temperature in air chamber: 20°C
- Saturated vapour
- Duration of exposure:
- 8 h
- No. of animals per sex per dose:
- 6
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 1 days
Results and discussion
- Mortality:
- No mortality was observed.
- Clinical signs:
- other: attempt to escape, closure eyelid, eye irritation
- Body weight:
- No adverse effects observed.
- Gross pathology:
- Nothing abnormal detected.
Applicant's summary and conclusion
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