Registration Dossier
Registration Dossier
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EC number: 236-882-0 | CAS number: 13531-52-7
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1976 - 1977
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Meets generally accepted scientific standards, well documented and acceptable for assessment.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 977
- Report date:
- 1977
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- not specified
- Principles of method if other than guideline:
- BASF Test, see details in remarks on material and methods
- GLP compliance:
- no
Test material
- Reference substance name:
- N-(2-aminoethyl)-1,3-propanediamine
- EC Number:
- 236-882-0
- EC Name:
- N-(2-aminoethyl)-1,3-propanediamine
- Cas Number:
- 13531-52-7
- Molecular formula:
- C5H15N3
- IUPAC Name:
- N1-(2-Aminoethyl)-1,3-propanediamine
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- Vienna White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: male: 3.42 kg; male: 2.75 kg
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- clipped
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: untreated skin of the same animals served as control.
- Amount / concentration applied:
- TEST MATERIAL
- Amount applied: 1 mL - Duration of treatment / exposure:
- 20 h
- Observation period:
- 2 days
- Number of animals:
- 2
- Details on study design:
- TEST SITE
- Area of exposure: 2.5 x 2.5 cm
Results and discussion
In vivo
Results
- Irritation parameter:
- other: Necrosis in all 2 animals after 1 min, 5 min, 15 min or 20 hours treatment
- Basis:
- mean
- Time point:
- other: 24 h
- Reversibility:
- not reversible
- Remarks on result:
- other: Both animals died 2 days after exposure.
- Irritant / corrosive response data:
- Based on the necrosis observed 24 hours after 1 min, 5 min, 15 min or 20 min treatment, the test substance is corrosive to the rabbit skin and should be classified according to the EU (R35) and to GHS (Cat 1A).
- Other effects:
- All 2 animals died within 2 days.
Any other information on results incl. tables
Both animals died 2 days after exposure. Based on corrosive effects, the substance has to be judged as corrosive to skin.
Applicant's summary and conclusion
- Interpretation of results:
- corrosive
- Remarks:
- Migrated information Cat 1A Criteria used for interpretation of results: OECD GHS
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