Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 220-342-6 | CAS number: 2726-73-0
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation
- Remarks:
- other: calculation
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The QSAR result meets the conditions listed in REACH (EC 1906/2006) ANNEX XI 1.3.
- Justification for type of information:
- QSAR prediction: migrated from IUCLID 5.6
Data source
Reference
- Reference Type:
- other: company data
- Title:
- Unnamed
- Year:
- 2 014
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: REACH guidance on QSARs R.6, May/July 2008
- Principles of method if other than guideline:
- TIMES-SS 2.27.13 - Skin sensitization v. 18.21 with autoxidation (Structure-toxicity and structure-metabolism relationships)
- GLP compliance:
- no
- Type of study:
- other: Calculation QSAR
Test material
- Reference substance name:
- Octadecane-1,12-diol
- EC Number:
- 220-342-6
- EC Name:
- Octadecane-1,12-diol
- Cas Number:
- 2726-73-0
- Molecular formula:
- C18H38O2
- IUPAC Name:
- octadecane-1,12-diol
- Details on test material:
- SMILES: CCCCCCC(O)CCCCCCCCCCCO
The prediction is made for the substance of high purity (compare chapter 1.3)
Constituent 1
Results and discussion
Any other information on results incl. tables
The QSAR program calculated a negative sensitization potential of the test substance. The substance is in domain of the system.
Applicant's summary and conclusion
- Interpretation of results:
- not sensitising
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The QSAR program calculated a negative sensitization potential of the test substance. The substance is in domain of the system.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
