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Diss Factsheets
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EC number: 203-199-4 | CAS number: 104-40-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Data from study report
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 982
Materials and methods
- Principles of method if other than guideline:
- Skin corrosivity evaluation of 4-Nonylphenol in rabbit.
- GLP compliance:
- no
Test material
- Reference substance name:
- p-nonylphenol
- EC Number:
- 203-199-4
- EC Name:
- p-nonylphenol
- Cas Number:
- 104-40-5
- Molecular formula:
- C15H24O
- IUPAC Name:
- 4-nonylphenol
- Details on test material:
- - Name of test material (as cited in study report): Nonylphenol
- Molecular formula (if other than submission substance): C15-H24-O
- Molecular weight (if other than submission substance): 220.354 g/mol
- Substance type: Organic
- Physical state: Solid
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- Details on test animal
TEST ANIMALS
- Source: Dutchland Laboratories, Inc.
Denver, Pennsylvania
- Age at study initiation: Young adults
- Weight at study initiation: No data available
- Fasting period before study: No data available
- Housing: Individually housed, Suspended, stainless steel cage.
- Diet (e.g. ad libitum): Purina lab Rabbit Chow HF (#5326), ad libitum
- Water (e.g. ad libitum): automatic watering system, ad libitum Municipal water supply (Elizabethtown water Co.)
- Acclimation period: No data available
Or Test Tissue
- Source: No data available
- Type: No data available
- Acclimation : No data available
- Housing conditions:
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 60-70°F
- Humidity (%): monitored daily
- Air changes (per hr): No data available
- Photoperiod (hrs dark / hrs light): 12 hours light, 12 hours dark
IN-LIFE DATES: From: To: No data available
Test system
- Type of coverage:
- other: Plastic sheeting was wrapped around the animals and secured with tape
- Preparation of test site:
- other: On the day before dosing the hair of each rabbit was closely clipped from the back with an electric clipper, so as to expose the back from the scapular to the lumbar region. The skin at the site remained intact; no abrasions were made.
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not specified
- Amount / concentration applied:
- 0.5 ml
- Duration of treatment / exposure:
- 4 h
- Observation period:
- 48 h
- Number of animals:
- Six (3 male & 3 female)
- Details on study design:
- Details on study design
TEST SITE
- Area of exposure: left side of the spinal
column
- % coverage: No data available
- Type of wrap if used: Plastic sheeting
REMOVAL OF TEST SUBSTANCE
- Washing (if done): the test sites wiped free of excess test material with castile soap and water.
- Time after start of exposure: No data available
SCORING SYSTEM: No data available
Results and discussion
In vivo
Results
- Irritation parameter:
- other: erythema and edema, corrosivity and tissue damage (necrotic skin)
- Basis:
- mean
- Time point:
- other: 48 Hr
- Reversibility:
- no data
- Remarks on result:
- other: other details not known
- Irritant / corrosive response data:
- corrosive to the rabbit skin.
Applicant's summary and conclusion
- Interpretation of results:
- corrosive
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The substance Nonylphenol is corrosive to the rabbit skin.
- Executive summary:
Skin irritation test of Nonylphenol was conducted inNew Zealand WhiteAlbino rabbit. 0.5 ml of the test substance was applied on the clipped back skin of rabbit for 4 h. At termination of the study (48 hours). However, all animals exhibited evidence of corrosivity and tissue damage {necrotic skin). Thus, under conditions of this study, Nonylphenol is corrosive to the skin.
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