Registration Dossier
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EC number: 202-155-1 | CAS number: 92-43-3
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
The study outlines the effect of test chemical on the fresh water fish danio rerio, which is conducted by following the OECD Guideline 203 (Fish, Acute Toxicity Test).Test solution is prepared by dissolving the test chemical in potable water. Test performed with one negative control (replicates=2) and along various test concentrations (replicates=2) i.e., 0.625mg/L,1.25mg/L,2.5mg/L,5mg/L, and 10mg/L. Study was led under static conditions for the period of 96 h. The experiment was daily observed at an interval of 24 hr (24, 48, 72, and 96h), for any mortality and physical abnormalities in the exposed groups.
After the exposure tenure of 96 h, based on the mortality of fish, median lethal concentration and LC0 concentrations were evaluated. The lethal concentration zero (LC0) and median lethal concentration (LC50) of test chemical was determined to be 10 mg/L and >10 mg/L, respectively. Based on the LC50, it can be consider that the chemical is hazardous to fresh water fish and can be consider to be classified aquatic chronic 3 as per CLP classification criteria.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 10 mg/L
Additional information
In the following information from experimental studies report and different peer reviewed journal on short term toxicity testing to fish for target chemical is summarized:
The study outlines the effect of test chemical on the fresh water fish danio rerio, which is conducted by following the OECD Guideline 203 (Fish, Acute Toxicity Test).Test solution is prepared by dissolving the test chemical in potable water. Test performed with one negative control (replicates=2) and along various test concentrations (replicates=2) i.e., 0.625mg/L,1.25mg/L,2.5mg/L,5mg/L, and 10mg/L. Study was led under static conditions for the period of 96 h. The experiment was daily observed at an interval of 24 hr (24, 48, 72, and 96h), for any mortality and physical abnormalities in the exposed groups.
After the exposure tenure of 96 h, based on the mortality of fish, median lethal concentration and LC0 concentrations were evaluated. The lethal concentration zero (LC0) and median lethal concentration (LC50) of test chemical was determined to be 10 mg/L and >10 mg/L, respectively. Based on the LC50, it can be consider that the chemical is hazardous to fresh water fish and can be consider to be classified aquatic chronic 3 as per CLP classification criteria.
Short term toxicity test was performed on freshwater fish for 24 hrs under static condition. Lethal concentration to 100% of test organisms was observed, therefore theLC100 of test chemical to Pimephales promelas was determined to be 50mg/l.
Short term toxicity test was performed on freshwater fish for 96 hrs under static condition. Lethal concentration to 100% of test organisms was observed, therefore the LC50 of test chemical to Pimephales promelas was determined to be in the range of 1 -10 mg/l.
Based on the effect concentration derived from experimental report, we can conlude that test chemical has toxic effect on fish and can be considered to be classified as aquatic chronic 3 as per CLP.
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