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Diss Factsheets
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EC number: 700-376-2 | CAS number: 1015689-48-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://poisoncentres.echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2008-06-05 to 2008-07-07
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: OECD Guideline study report, test prepared according to request of Swiss authority
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 008
- Report date:
- 2008
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Reaction mass of (3R,3aS,6R,6aS)-6-[(4-{[4-(acryloyloxy)benzoyl]oxy}-3-methoxybenzoyl)oxy]hexahydrofuro[3,2-b]furane-3-yl 4-{[4-(acryloyloxy)benzoyl]oxy}-3-methoxybenzoate and (3R,3aR,6R,6aR)-6-(4-(4-(acryloyloxy)benzoyloxy)-3-methoxybenzoyloxy)hexahydrofuro[3,2-b]furan-3-yl 4-(4-(4-(acryloyloxy)benzoyloxy)benzoyloxy)-3-methoxybenzoate + Isomers and (3R,3aR,6R,6aR)-6-(4-(4-(4-(acryloyloxy)benzoyloxy)-3- methoxybenzoyloxy)-3-methoxybenzoyloxy)hexahydrofuro[3,2-b]furan-3-yl 4-(4-(acryloyloxy)benzoyloxy)-3-methoxybenzoate + Isomers
- IUPAC Name:
- Reaction mass of (3R,3aS,6R,6aS)-6-[(4-{[4-(acryloyloxy)benzoyl]oxy}-3-methoxybenzoyl)oxy]hexahydrofuro[3,2-b]furane-3-yl 4-{[4-(acryloyloxy)benzoyl]oxy}-3-methoxybenzoate and (3R,3aR,6R,6aR)-6-(4-(4-(acryloyloxy)benzoyloxy)-3-methoxybenzoyloxy)hexahydrofuro[3,2-b]furan-3-yl 4-(4-(4-(acryloyloxy)benzoyloxy)benzoyloxy)-3-methoxybenzoate + Isomers and (3R,3aR,6R,6aR)-6-(4-(4-(4-(acryloyloxy)benzoyloxy)-3- methoxybenzoyloxy)-3-methoxybenzoyloxy)hexahydrofuro[3,2-b]furan-3-yl 4-(4-(acryloyloxy)benzoyloxy)-3-methoxybenzoate + Isomers
- Details on test material:
- Name: 2MeO3-Im4KA2
Batch no.: AC425/428/429/430
Chemical name: (3R,3aS, 6R,6aS)-6-[(4-{[4-(acryloyloxy) benzoyl]oxy}-3-methoxybenzoyl)oxy] hexahydrofuro[3,2-b]furan-3-yl 4-{[4-
(acryloyloxy)benzoyl]oxy}-3- methoxybenzoate
Purpose: industrial chemical
Colour: beige
Physical state: powder
Stability in solution
or suspension: probably stable
Special procedures
for dose preparation: prepare freshly
Storage: at room temperature, protected from light
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- ealthy New Zealand White Rabbits HsdIf:NZW, body weight at the beginning of the study > 2 kg.
Source: Harlan Winkelmann GmbH, D-33178 Borchen
Three female animal were used.
The animals were derived from a controlled full barrier maintained breeding system (SPF).
- Semi-barrier in an air conditioned room
- Temperature: 18 ± 3°C (recommendations of TVT, GV-SOLAS; see
References)
- Relative humidity: 55 ± 10%
- Artificial light, sequence being 12 hours light, 12 hours dark
- Air change: at least 10 x / hour
- Free access to Altromin 2123 maintenance diet for rabbits, rich in crude
fibre
- Free access to tap water (drinking water, municipal residue control,
microbiol. controlled periodically)
- Certificates of food, water and bedding are filed at the testing facility
- Housed in ABS - plastic rabbit cages, floor 4200 cm2
- Adequate acclimatization period (at least 5 days)
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- other: clipped
- Vehicle:
- unchanged (no vehicle)
- Controls:
- yes, concurrent no treatment
- Amount / concentration applied:
- A dose of 0.5 g of the test item was applied to each test site.
- Duration of treatment / exposure:
- The test item was held in contact with the skin throughout a 4-hour period.
- Observation period:
- The animals were examined for signs of erythema and oedema at 1, 24, 48 and 72 hours after patch removal.
- Number of animals:
- 3
- Details on study design:
- The test item was applied as a single dose to a small area (approx. 6 cm²) of skin on one side of the dorsal area and covered with a gauze patch, which was held in place with non-irritating tape. The untreated other side served as control. The test item was applied to the patch first, and then applied to the skin. The patch was fixed with a semi-occlusive dressing.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: any
- Score:
- 0
- Max. score:
- 0
- Remarks on result:
- other: none
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: any
- Score:
- 0
- Max. score:
- 0
- Remarks on result:
- other: none
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: any
- Score:
- 0
- Max. score:
- 0
- Remarks on result:
- other: none
- Irritant / corrosive response data:
- For the determination of classification-relevant values, the animals were examined for signs of erythema and oedema at 24, 48 and 72 hours after patch removal. Dermal irritation was scored and recorded according to the grades in the table below. Any other signs such as hyperplasia, scaling, discoloration, fissures and scabs or any systemic effects were also recorded.
Erythema and Eschar Formation
No erythema 0
Very slight erythema (barely perceptible) 1
Well-defined erythema 2
Moderate to severe erythema 3
Severe erythema (beef-redness) to eschar formation 4
preventing grading of erythema
Oedema formation
No oedema 0
Very slight oedema (barely perceptible) 1
Slight oedema
(edges of area well defined by definite raising) 2
Moderate oedema (raised approx. 1 mm) 3
Severe oedema (raised more than 1 mm and extending
beyond exposure area) 4 - Other effects:
- none reported
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Substance is not irritating to the skin.
- Executive summary:
2MeO3-Im4KA2 was administered on the clipped skin of 3 female New Zealand White Rabbits HsdIf:NZW at a concentration of 0.5 g and a contact area of 6 cm2 for 4 hours by a semi-occlusive dressing according to OECD guideline 404. The substance was moistened with aqua ad injectionem. The clipped other side served as a control. Limit values according to Directive 2001/59/EC. On the basis of the test results the substance should be not classified. The substance showed no effect at any observation time neither in the formation of oedema nor in the formation of erythema.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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