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EC number: 700-376-2 | CAS number: 1015689-48-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2008-06-05 to 2008-07-14
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: OECD Guideline study report, test prepared according to request of Swiss authority
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 008
- Report date:
- 2008
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Reaction mass of (3R,3aS,6R,6aS)-6-[(4-{[4-(acryloyloxy)benzoyl]oxy}-3-methoxybenzoyl)oxy]hexahydrofuro[3,2-b]furane-3-yl 4-{[4-(acryloyloxy)benzoyl]oxy}-3-methoxybenzoate and (3R,3aR,6R,6aR)-6-(4-(4-(acryloyloxy)benzoyloxy)-3-methoxybenzoyloxy)hexahydrofuro[3,2-b]furan-3-yl 4-(4-(4-(acryloyloxy)benzoyloxy)benzoyloxy)-3-methoxybenzoate + Isomers and (3R,3aR,6R,6aR)-6-(4-(4-(4-(acryloyloxy)benzoyloxy)-3- methoxybenzoyloxy)-3-methoxybenzoyloxy)hexahydrofuro[3,2-b]furan-3-yl 4-(4-(acryloyloxy)benzoyloxy)-3-methoxybenzoate + Isomers
- IUPAC Name:
- Reaction mass of (3R,3aS,6R,6aS)-6-[(4-{[4-(acryloyloxy)benzoyl]oxy}-3-methoxybenzoyl)oxy]hexahydrofuro[3,2-b]furane-3-yl 4-{[4-(acryloyloxy)benzoyl]oxy}-3-methoxybenzoate and (3R,3aR,6R,6aR)-6-(4-(4-(acryloyloxy)benzoyloxy)-3-methoxybenzoyloxy)hexahydrofuro[3,2-b]furan-3-yl 4-(4-(4-(acryloyloxy)benzoyloxy)benzoyloxy)-3-methoxybenzoate + Isomers and (3R,3aR,6R,6aR)-6-(4-(4-(4-(acryloyloxy)benzoyloxy)-3- methoxybenzoyloxy)-3-methoxybenzoyloxy)hexahydrofuro[3,2-b]furan-3-yl 4-(4-(acryloyloxy)benzoyloxy)-3-methoxybenzoate + Isomers
- Details on test material:
- Name: 2MeO3-Im4KA2
Batch no.: AC425/428/429/430
Chemical name: (3R,3aS, 6R,6aS)-6-[(4-{[4-(acryloyloxy) benzoyl]oxy}-3-methoxybenzoyl)oxy] hexahydrofuro[3,2-b]furan-3-yl 4-{[4-
(acryloyloxy)benzoyl]oxy}-3- methoxybenzoate
Purpose: industrial chemical
Colour: beige
Physical state: powder
Stability in solution
or suspension: probably stable
Special procedures
for dose preparation: prepare freshly
Storage: at room temperature, protected from light
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- Healthy New Zealand White Rabbits HsdIf:NZW.
Source: Harlan Winkelmann GmbH, D-33178 Borchen.
Three female animals were used. Body weight at the commencement of the study was >2.0 kg.
The animals were derived from a controlled full barrier maintained breeding system (SPF).
- Semi-barrier in an air conditioned room
- Temperature: 18 ± 3°C (recommendations of TVT, GV-SOLAS; see
References)
- Relative. humidity: 55 ± 10%
- Artificial light, sequence being 12 hours light, 12 hours dark
- Air change: at least 10 x / hour
- Free access to Altromin 2123 maintenance diet for rabbits, rich in crude fibre
- Free access to tap water (drinking water, municipal residue control, microbiol. controlled periodically)
- Certificates of food, water and bedding are filed at testing facility
- Housed in ABS - plastic rabbit cages, floor 4200 cm2
- Adequate acclimatization period (at least 5 days)
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- yes, concurrent no treatment
- Amount / concentration applied:
- A dose of 0.1 g of the test item was applied to the conjunctival sac of the eye.
- Duration of treatment / exposure:
- The eyes were examined for signs of irritation throughout the observation period.
For calculation only the 24 h, 48 h and 72 hour readings were used. - Observation period (in vivo):
- The animals were observed for 72 hours after dosing.
- Number of animals or in vitro replicates:
- 3
- Details on study design:
- The test item was applied in a single dose in the conjunctival sac of one eye of each test animal after pulling the lower lid away from the eyeball. The lids were then gently held together for about 1 second in order to prevent loss of the material. The untreated contralateral eye served as control.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- other: any
- Score:
- 0
- Max. score:
- 0
- Remarks on result:
- other: none
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- other: any
- Score:
- 0
- Max. score:
- 0
- Remarks on result:
- other: none
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- other: any
- Score:
- 0
- Max. score:
- 0
- Remarks on result:
- other: none
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- other: any
- Score:
- 0
- Max. score:
- 1
- Reversibility:
- fully reversible within: 48 h
- Remarks on result:
- other: none
- Irritant / corrosive response data:
- Initial Test (In Vivo Eye Irritation/Corrosion Test Using One Animal)
The in vivo test was performed initially using one animal.
As a corrosive effect was not observed in the initial test, the irritant or
negative response was confirmed using two additional animals.
Cornea: degree of density
(Opacity, area most dense taken for reading) Score
No ulceration or opacity 0
Scattered or diffuse areas of opacity (other than slight
dulling of normal lustre), details of iris clearly visible 1
Easily discernible translucent area,
details of iris slightly obscured 2
Nacreous area, no details of iris visible,
size of pupil barely discernible 3
Opaque cornea, iris not discernible through the opacity 4
Iris Score
Normal 0
Markedly deepened rugae, congestion, swelling, moderate
circumcorneal hyperaemia, or injection; iris reactive to
light (a sluggish reaction is considered to be an effect) 1
Hemorrhage, gross destruction, or no reaction to light 2
Conjunctivae Score
Redness (refers to palpebral and bulbar conjunctivae:
excluding cornea and iris)
Normal 0
Some blood vessels hyperaemic (injected) 1
Diffuse crimson colour, individual vessels not easily
Discernible 2
Diffuse beefy red 3
Chemosis
Swelling (refers to lids and/or nictitating membranes) Score
Normal 0
Some swelling above normal 1
Obvious swelling, with partial eversion of lids 2
Swelling, with lids about half closed 3
Swelling with lids more than half closed 4
Discharge Score
No discharge 0
Any amount different from normal 1
Discharge with moistening of the lids and hairs adjacent to
Lids 2
Discharge with moistening of the lids and hairs, and
considerable area around the eye 3 - Other effects:
- none reported
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Substance is not irritating to eyes.
- Executive summary:
2MeO3-Im4KA2 was comminuted and administered to the conjunctival sac of eyes of 3 female New Zealand White Rabbits HsdIf:NZW at a concentration of 0.1 g according to OECD guideline 405. The untreated eyes of the rabbits served as a control. Limit values according to Directive 2001/59/EC. On the basis of the test results the substance was not classified. The substance showed only very slight effects on conjunctivae, not on iris or on the cornea. These effects were fully reversible within 2 days.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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