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Diss Factsheets
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EC number: 204-496-1 | CAS number: 121-73-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Data is from peer reviewed journal
Data source
Reference
- Reference Type:
- secondary source
- Title:
- TOXICOLOGICAL EVALUATION
- Author:
- BG Chemie
- Year:
- 2 000
- Bibliographic source:
- BG Chemie InfoCenter TOXIKOLOGISCHE BEWERTUNGEN, last updated 11/2000
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as mentioned below
- Principles of method if other than guideline:
- Skin irritation study was conducted to test the effects of m chloronitrobenzene on new Zealand rabbits after 24 hr.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 1-chloro-3-nitrobenzene
- EC Number:
- 204-496-1
- EC Name:
- 1-chloro-3-nitrobenzene
- Cas Number:
- 121-73-3
- Molecular formula:
- C6H4ClNO2
- IUPAC Name:
- 1-chloro-3-nitrobenzene
- Details on test material:
- - Name of test material (as cited in study report): 1-chloro-3-nitrobenzene
- Molecular formula (if other than submission substance): C6H4ClNO2
- Molecular weight (if other than submission substance): 157.556 g/mol
- Smiles notation: c1(cc(ccc1)Cl)[N+](=O)[O-]
- InChl : 1S/C6H4ClNO2/c7-5-2-1-3-6(4-5)8(9)10/h1-4H
- Substance type: Solid
- Physical state: Organic
- Impurities (identity and concentrations): No data
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- No data available
Test system
- Type of coverage:
- other: semi-occlusive bandage with adhesive plaster
- Preparation of test site:
- not specified
- Vehicle:
- other: 0.3 ml propylene glycol
- Controls:
- not specified
- Amount / concentration applied:
- No data available
- Duration of treatment / exposure:
- 30 and 60 minutes
- Observation period:
- 24hr
- Number of animals:
- 3 animals
- Details on study design:
- No data available
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 24hrs
- Remarks on result:
- other: Non irritating, Hardly noticeable erythema
- Irritant / corrosive response data:
- No data available
- Other effects:
- No data available
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- m-Chloronitrobenzene was found to be non- irritating to skin.
- Executive summary:
m-Chloronitrobenzene was applied as a paste made with 0.3 ml propylene glycol, and covered with a semi-occlusive bandage which was affixed to the application site with ad-hesive plaster. Following the exposure period, the chemical was removed from the skin with lukewarm water. Assessments of the treated area of skin after 30 and 60 minutes revealed mild, hardly noticeable erythema in 2 animals. After 24 hours, the animals no longer showed any signs of irritation. Therefore, m-chloronitrobenzene was not irritating to the rabbit skin .
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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