Registration Dossier
Registration Dossier
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EC number: 224-208-8 | CAS number: 4247-02-3
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- calculation (if not (Q)SAR)
- Remarks:
- Migrated phrase: estimated by calculation
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- other: Authoritative data base
- Title:
- Danish QSAR study for CAS No.:4247-02-3
- Author:
- Danish (Q)SAR Database
- Year:
- 2 016
- Bibliographic source:
- Database developed by National Food Institute, Technical University of Denmark, with support from the Danish Environmental Protection Agency, the Nordic Council of Ministers and the European Chemicals Agency.
Materials and methods
- Principles of method if other than guideline:
- The data predicted using the Danish (Q)SAR Database
- GLP compliance:
- no
Test material
- Reference substance name:
- Isobutyl 4-hydroxybenzoate
- EC Number:
- 224-208-8
- EC Name:
- Isobutyl 4-hydroxybenzoate
- Cas Number:
- 4247-02-3
- Molecular formula:
- C11H14O3
- IUPAC Name:
- 2-methylpropyl 4-hydroxybenzoate
- Details on test material:
- - Name of test material: Isobutyl 4-hydroxybenzoate
- Molecular formula: C11H14O3
- Molecular weight: 194.23 g/mol
- Substance type: Organic
- Physical state: Solid
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
Test system
- Type of coverage:
- not specified
- Preparation of test site:
- not specified
- Vehicle:
- not specified
- Controls:
- not specified
- Duration of treatment / exposure:
- no data
- Observation period:
- no data
- Number of animals:
- no data
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Remarks on result:
- other: not Skin irritant
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Based on the QSAR prediction done using the Danish (Q)SAR Database, the skin irritation was estimated to be negative on rabbits for Isobutyl 4-hydroxybenzoate. Thus it can be concluded that the substance Isobutyl 4-hydroxybenzoate has negative skin irritation effects.
- Executive summary:
Based on the QSAR prediction done using the Danish (Q)SAR Database, the skin irritation was estimated to be negative on rabbits for Isobutyl 4-hydroxybenzoate. Thus it can be concluded that the substance Isobutyl 4-hydroxybenzoate has negative skin irritation effects.
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