Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

LLNA (OECD 429): not sensitising

Key value for chemical safety assessment

Skin sensitisation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not sensitising)
Additional information:

In a LLNA skin sensitisation study (WIL research, 2016), performed according to OECD 429 test guideline and GLP principles, isobutyl 4-hydroxybenzoate was considered not to be a skin sensitiser, as the SI appeared not to be ≥ 3 when tested up to and including 60% (v/v) isobutyl 4-hydroxybenzoate.

Respiratory sensitisation

Endpoint conclusion
Endpoint conclusion:
no study available

Justification for classification or non-classification

The available data on skin sensitisation do not meet the criteria for classification according to Regulation (EC) 1272/2008 and are threrefore conclusive but not sufficient for classification.