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Diss Factsheets
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EC number: 700-678-4 | CAS number: 1076-12-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 11 October to 13 October 2011
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 012
- Report date:
- 2012
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 437 (Bovine Corneal Opacity and Permeability Test Method for Identifying Ocular Corrosives and Severe Irritants)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- TCD
- IUPAC Name:
- TCD
- Test material form:
- gas under pressure: refrigerated liquefied gas
- Details on test material:
- - Name of test material (as cited in study report): Tetracyclo[4.4.0.1(2,5).1(7,10)]dodeca-3-ene
- Substance type: Monomer for polycycloolefin production
- Physical state:Transparent liquid
- Analytical purity: 100%
- Lot/batch No.: M0904
- Expiration date of the lot/batch: 31 December 2013
- Storage condition of test material: Refrigerated (ca 4°C), in the dark, under N2
Constituent 1
Test animals / tissue source
- Species:
- other: Bovine eyes
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- yes
- Amount / concentration applied:
- TEST MATERIAL
- Amount applied: 750 µl - Duration of treatment / exposure:
- 10 min ± 30 s
- Observation period (in vivo):
- n/a
- Number of animals or in vitro replicates:
- n/a
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing (if done):
- Time after start of exposure: 2 h 10 m
SCORING SYSTEM: opacitometer
TOOL USED TO ASSESS SCORE: fluorescein
Results and discussion
In vitro
Results
- Irritation parameter:
- in vitro irritation score
- Value:
- 1.5
- Vehicle controls validity:
- not applicable
- Negative controls validity:
- valid
- Positive controls validity:
- valid
- Other effects / acceptance of results:
- Throughout the assay the corneas were examined for opaque spots or other irregularities. Following treatment with test substance, TCD, the corneas were noted as clear. The corneas treated with the positive control, sodium hydroxide 10% (w/v), were very opaque and the corneas treated with the negative control, 0.9 % saline, were clear.
Any other information on results incl. tables
The test substance was diluted to 10 % w/v with 0.9 % saline to obtain an aqueous solution for pH measurement. The pH of the test sample, measured using universal pH sticks, was approximately 7.0.
The positive control, sodium hydroxide (10 %), elicited an In Vitro Irritancy Score of 277.1 ± 19.1. This value was within the historical range (mean ± 2 x SD, 256.5 - 314.9) for the assays performed to date.
The negative control, 0.9 % saline, opacity mean change value was 1.0 which was below the maximum acceptance value of 2.0. The permeability mean of the negative control was 0.018 which was below the maximum acceptance value of 0.1.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The test substance, TCD, elicited an In Vitro Irritancy Score of 1.5 ± 0.7 and was predicted to be a non-corrosive/ non-severe eye irritant.
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