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Diss Factsheets
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EC number: 200-957-6 | CAS number: 76-39-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation / corrosion, other
- Remarks:
- Study was in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- March1980
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
- Report date:
- 1980
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- EPA OPP 81-5 (Acute Dermal Irritation)
- Version / remarks:
- Following a four hour exposure sites were visually scored for edema, erythema and tissue destruction at 4, 24 and 48 hours
- Deviations:
- not applicable
- Principles of method if other than guideline:
- The skin corrosion potential of the test substance was assessed in rabbits. 0.5 g of the test substance were applied on the shaved back of each animal, which was covered with an occlusive dressing. After 4 hours, the skin area was cleaned and the skin sites were examined for erythema and edema. The skin sites were examined again 24 and 48 hours after exposure.
- GLP compliance:
- no
Test material
- Reference substance name:
- 2-methyl-2-nitropropan-1-ol
- EC Number:
- 200-957-6
- EC Name:
- 2-methyl-2-nitropropan-1-ol
- Cas Number:
- 76-39-1
- Molecular formula:
- C4H9NO3
- IUPAC Name:
- 2-methyl-2-nitropropan-1-ol
- Details on test material:
- Purity is above 99%.
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): P-184 or NMP Crystals ( 2-nitro-2-methyl-1-propanol) Lot # C-027907 CAS Number 76-39-1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS: Weight at study initiation: 3.0 ± 0.5 kg
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- 0.5 g powder per site
- Duration of treatment / exposure:
- 4 hours
- Observation period:
- 48 hours
- Number of animals:
- 6
- Details on study design:
- The skin sites were examined for erythema, edema and tissue destruction 4, 24 and 48 hours after exposure. - Area of exposure: The skin from the back area of each rabbit was shaved free of hair. 0.5 g of the test substance was applied and the back was covered with a fabric patch and occluded with tape. The entire trunk was loosely wrapped with an impervious rubber cloth and by a stainless steel protective screen held in place by tape. Following a 4 hour exposure the patched were removed, the treated sites cleaned and visually examined for erythema, edema and tissue destruction at 4, 24 and 48 hours following exposureSkin reactions of erythema, edema, or tissue destruction was noted and recorded. Any tissue destruction will be scored as a positive reaction (according to Draize, Association of Food and Drug O f f i c i a l s of the United States, p. 48, 1959).
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 48 h
- Score:
- 0
- Reversibility:
- other: Not applicable
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 48 h
- Score:
- 0
- Reversibility:
- other: Not applicable
- Irritant / corrosive response data:
- No erythema, edema or corrosion was reported at any time during the observation period.
- Other effects:
- No data.
Any other information on results incl. tables
Corrosion results
Irritation parameter |
Basis |
Time point |
Score |
Reversibility |
Remarks |
erythema score |
mean (of all 6 animals) |
4,24,48 hr |
0 |
other: reversibility not applicable |
|
edema score |
mean (of all 6 animals) |
4,24,48 ht |
0 |
other: reversibility not applicable |
|
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Not corrosive to the skin.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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