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Diss Factsheets
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EC number: - | CAS number: 20126-76-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 05 to 12 September 2016
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- flask method
- Key result
- Water solubility:
- 2.81 g/L
- Temp.:
- 20 °C
- pH:
- 6.6
- Conclusions:
- A water solubility value of 2.81 g/L (at 20 °C, pH 6.6) was determined for the test substance according to E.U. Method A.6.
- Executive summary:
The water solubility of the test item was determined according to OECD guideline 105 (1995) and GLP. Based on the result of a preliminary test, the definitive test was dertmined using the flask method at 20 ± 0.5 °C with pre-incubation at 30 ± 0.5 °C. The concentration was analyzed via HPLC method with diode array detection (DAD). The water solubility of the test item was determined to be 2.81 g/L at 20 °C and pH6.6.
Reference
Results
Preliminary Test
The determined solubility in double distilled water was in the range of 210 - 525 mg/L. For the application dose for the definitive study, approx. 3 g/L was used (approximately five times the maximum solubility result).
Main Test
The results of the sampling are reported in the table below. No significant signals were obtained for the control sample. Undissolved test item was observed in all samples before sample preparation.
Water Solubility Results at 20 °C for the test item
Preincubation time |
Replicate No. |
Concentration [1] (g/L) |
Mean (g/L) |
24 h |
1 |
2.76 |
2.79 |
2 |
2.81 |
||
48 h |
1 |
2.84 |
2.81 |
2 |
2.78 |
||
72 h |
1 |
2.78 |
2.83 |
2 |
2.89 |
||
Mean (24 - 72 h) |
|
|
2.81 |
Deviation [%] (24 - 72 h) [2] |
|
|
1.7 |
[1] Mean value of two injections, dilution factor of 40 and exact weight of the standard taken into account
[2] Calculated according to the formula: Deviation [%] = 100 x (max value - min value) / min value
Validity Criteria
The validity criteria were fulfilled:
- The concentration measured for the two longest incubation times did not differ by more than 15%.
- Temperatures were kept constant within ± 0.5 °C.
Conclusions
The solubility of the test item was determined at 20 + 0.5 °C to be 2.81 g/L (pH 6.6).
Description of key information
Water solubility: 2.81 g/L at 20 °C, pH 6.6 (E.U. Method A.6, flask method)
Key value for chemical safety assessment
- Water solubility:
- 2.81 g/L
- at the temperature of:
- 20 °C
Additional information
The water solubility of the test item was determined according to OECD guideline 105 (1995) and GLP. Based on the result of a preliminary test, the definitive test was dertmined using the flask method at 20 ± 0.5 °C with pre-incubation at 30 ± 0.5 °C. The concentration was analyzed via HPLC method with diode array detection (DAD). The water solubility of the test item was determined to be 2.81 g/L at 20 °C and pH6.6.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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