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EC number: 213-059-4 | CAS number: 920-66-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Repeated dose toxicity: inhalation
Administrative data
- Endpoint:
- repeated dose toxicity: inhalation, other
- Remarks:
- 10 exposures of 4 h/day
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1966, no further information.
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- significant methodological deficiencies
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 966
- Report date:
- 1966
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- - Principle of test:
Daily 4 h exposures to the test substance were made over a period of 10 days. Observations were made in comparison to a control group that was similarly exposed without the test substance.
- Short description of test conditions:
The test substance was metered into a T-tube, volatilized, diluted with air, and passed into an exposure chamber containing 6 rats. The same group of rats was exposed 4 h per day for 10 exposures, averaging 300 ppm. Half of the rats were sacrificed for histopathologic examination after the tenth exposure, and the other half were sacrificed after a 14-day recovery period. A control group of 6 rats was exposed to air, and sacrificed according to the same schedule. The chamber atmosphere was analysed by a gas chromatographic procedure an average of 4 times per exposure, with results averaging 300 ± 24 ppm test substance.
- Parameters analysed / observed:
Initial body weights were measured, exposure chamber atmosphere was analyzed, and histopathologic examinations were conducted at the end of the exposure period, and at post-recovery, findings were recorded. - GLP compliance:
- no
- Remarks:
- pre-GLP
- Limit test:
- yes
Test material
- Reference substance name:
- 1,1,1,3,3,3-hexafluoropropan-2-ol
- EC Number:
- 213-059-4
- EC Name:
- 1,1,1,3,3,3-hexafluoropropan-2-ol
- Cas Number:
- 920-66-1
- Molecular formula:
- C3H2F6O
- IUPAC Name:
- 1,1,1,3,3,3-hexafluoropropan-2-ol
- Test material form:
- liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: ChR-CD
- Details on species / strain selection:
- None specified
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- None specified
Administration / exposure
- Route of administration:
- inhalation
- Type of inhalation exposure:
- other: vapour
- Vehicle:
- air
- Analytical verification of doses or concentrations:
- yes
- Details on analytical verification of doses or concentrations:
- gas chromatographic procedure, four times per exposure.
- Duration of treatment / exposure:
- 4 h
- Frequency of treatment:
- daily / ten exposures
Doses / concentrations
- Dose / conc.:
- 300 ppm (analytical)
- Remarks:
- standard deviation of ±24 ppm
- No. of animals per sex per dose:
- 6 male
- Control animals:
- yes
Examinations
- Observations and examinations performed and frequency:
- CAGE SIDE OBSERVATIONS: Yes
- Time schedule: no data
DETAILED CLINICAL OBSERVATIONS: Yes
- Time schedule: no data
BODY WEIGHT: Yes
- Time schedule for examinations: initial body weights taken before first exposure - Sacrifice and pathology:
- GROSS PATHOLOGY: Yes / No further information given
HISTOPATHOLOGY: Yes / Tissues examined: trachea, lung, kidney, liver, epididymis, testis, adrenal, brain, pituitary, esophagus, stomach, duodenum, pancreas, heart, bone marrow, thymus, thyroid and parathyroid, spleen, eye and lymph node. Special organ removal and sectioning techniques were used to examine for evidence of oligospermia or aspermia.
Results and discussion
Results of examinations
- Clinical signs:
- effects observed, treatment-related
- Description (incidence and severity):
- The first week the test rats exhibited blinking, lacrimation, salivation, nasal discharge, unresponsiveness, irregular breathing and mild hyperaemia during the exposure. Mild exophthalmos was observed immediately after the first few exposures. During the second week, mild chromodacryorrhea and eye discharge also were evident. No abnormal signs were observed during the recovery period. Growth was normal and comparable to that of the control rats. The vapours of HFIP at an atmospheric level of 300 ppm caused clinical signs indicative of respiratory irritation. However, repeated exposure at this level did not cause any discernible tissue changes that correlated to the clinical signs observed.
- Mortality:
- no mortality observed
- Body weight and weight changes:
- no effects observed
- Description (incidence and severity):
- Initial body weights: 242-278 g. Growth was normal and comparable to that of the controls.
- Food consumption and compound intake (if feeding study):
- not examined
- Food efficiency:
- not examined
- Water consumption and compound intake (if drinking water study):
- not examined
- Ophthalmological findings:
- not examined
- Haematological findings:
- not examined
- Clinical biochemistry findings:
- not examined
- Urinalysis findings:
- not examined
- Behaviour (functional findings):
- not examined
- Immunological findings:
- not examined
- Organ weight findings including organ / body weight ratios:
- not examined
- Gross pathological findings:
- no effects observed
- Neuropathological findings:
- not specified
- Histopathological findings: non-neoplastic:
- no effects observed
- Histopathological findings: neoplastic:
- not specified
- Other effects:
- no effects observed
- Description (incidence and severity):
- No evidence of oligospermia or aspermia.
Effect levels
- Key result
- Dose descriptor:
- NOAEC
- Effect level:
- ca. 300 ppm (analytical)
- Based on:
- test mat.
- Sex:
- male
- Basis for effect level:
- clinical signs
Applicant's summary and conclusion
- Conclusions:
- CLP/EU GHS criteria are not met, no classification required according to Regulation (EC) No 1272/2008. This study was conducted prior to publication (1981) of the OECD Test Guideline requirements for either acute, or repeated dose inhalation studies. Although the in vivo data is old and study reliability may be that of reliability 3, results of repeated exposure to the test substance at this level showed evidence of initial respiratory irritation, but did not cause any discernable tissue changes.
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