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EC number: 273-727-6 | CAS number: 69012-27-7 By-product of chromium refining containing oxides of aluminum, magnesium and silicon.
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Epidemiological data
Administrative data
- Endpoint:
- epidemiological data
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Dtech
Data source
Reference
- Reference Type:
- other: evaluation
- Title:
- Unnamed
- Year:
- 2 003
Materials and methods
- Study type:
- other: evaluation of the Health Council of the Netherlands
- Endpoint addressed:
- repeated dose toxicity: inhalation
Test guideline
- Qualifier:
- no guideline required
- Principles of method if other than guideline:
- evaluation of an authoritative instituition
- GLP compliance:
- no
Test material
- Reference substance name:
- Perlite
- EC Number:
- 603-442-8
- IUPAC Name:
- Perlite
- Reference substance name:
- 93763-70-3
- EC Number:
- 618-970-4
- Cas Number:
- 93763-70-3
- IUPAC Name:
- 93763-70-3
Constituent 1
Constituent 2
Method
- Type of population:
- occupational
- Ethical approval:
- not specified
Results and discussion
- Results:
- In 3 long-term occupational studies in the USA, conducted in the period 1972-1983 on groups of 450, 117, and 152 workers, no evidence of a relationship between working in the perlite industry and the development of lung fibrosis (pneumoconiosis) was found. Tests included chest radiography and lung function parameters FVC and FEV1. No data on personal air exposures were reported, but workplace monitoring in the plants showed that airborne concentrations were close to the nuisance dust level of 10 mg/m3. No data were provided on the percentage of quartz in the per
Applicant's summary and conclusion
- Conclusions:
- No evidence of a relationship between working in the perlite industry and the development of lung fibrosis (pneumoconiosis) has been found.
- Executive summary:
In 3 long-term occupational studies in the USA, conducted in the period 1972-1983 on groups of 450, 117, and 152 workers, no evidence of a relationship between working in the perlite industry and the development of lung fibrosis (pneumoconiosis) was found. Tests included chest radiography and lung function parameters FVC and FEV1. No data on personal air exposures were reported, but workplace monitoring in the plants showed that airborne concentrations were close to the nuisance dust level of 10 mg/m3. No data were provided on the percentage of quartz in the perlite.
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