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Diss Factsheets

Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data is from peer-reviewed journal

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Fragrance raw materials monographs :Benzaldehyde
Author:
D. L. J. Opdyke
Year:
1976
Bibliographic source:
Food and Cosmetics Toxicology,Volume 14, Supplement, Pages 659-893 (1976)
Reference Type:
publication
Title:
Acute dermal toxicity study of Benzaldehyde (100-52-7)
Author:
Wiley-VCH Verlag GmbH & Co. KGaA
Year:
2012
Bibliographic source:
The MAK Collection for Occupational Health and Safety, Volume 17,31 JAN 2012

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: As mentioned below
Principles of method if other than guideline:
Acute dermal toxicity study of Benzaldehyde (100-52-7) was performed in rabbits.
GLP compliance:
not specified
Test type:
other: No data available
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Benzaldehyde
EC Number:
202-860-4
EC Name:
Benzaldehyde
Cas Number:
100-52-7
Molecular formula:
C7H6O
IUPAC Name:
Benzaldehyde
Details on test material:
- Name of test material (IUPAC name): Benzaldehyde
- Common name: Benzaldehyde
- Molecular formula: C7H6O
- Molecular weight: 106.1234 g/mol
- Smiles notation: c1ccc(cc1)C=O
- InChl: 1S/C7H6O/c8-6-7-4-2-1-3-5-7/h1-6H
- Substance type: Organic
Specific details on test material used for the study:
- Name of test material (IUPAC name): Benzaldehyde
- Common name: Benzaldehyde
- Molecular formula: C7H6O
- Molecular weight: 106.1234 g/mol
- Smiles notation: c1ccc(cc1)C=O
- InChl: 1S/C7H6O/c8-6-7-4-2-1-3-5-7/h1-6H
- Substance type: Organic

Test animals

Species:
rabbit
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
No data available

Administration / exposure

Type of coverage:
occlusive
Vehicle:
not specified
Details on dermal exposure:
No data available
Duration of exposure:
Duration of exposure:24 hours
Doses:
1250 mg/kg bw
No. of animals per sex per dose:
No data available
Control animals:
not specified
Details on study design:
No data available
Statistics:
No data available

Results and discussion

Preliminary study:
No data available
Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 1 250 mg/kg bw
Based on:
test mat.
Remarks on result:
other: No mortality was observed in treated rabbits at dose 1250 mg/kg bw
Mortality:
No mortality was observed in treated rabbits at dose 1250 mg/kg bw
Clinical signs:
No data available
Body weight:
No data available
Gross pathology:
No data available
Other findings:
No data available

Applicant's summary and conclusion

Interpretation of results:
Category 4 based on GHS criteria
Conclusions:
The LD50 value was considered to be >1250 mg/kg bw,when rabbits were treated with Benzaldehyde (100-52-7) by dermal application.
Executive summary:

In acute dermal toxicity study, rabbits were treated with Benzaldehyde(100-52-7)in the concentration of 1250 mg/kg bw by dermal application. No mortality was observed in treated rabbits at dose 1250 mg/kg bw. Therefore, LD50 value was considered to be >1250 mg/kg bw,when rabbits were treated with Benzaldehyde(100-52-7)by dermal application.