Registration Dossier
Registration Dossier
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EC number: 205-450-3 | CAS number: 141-04-8
Short-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1994
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 996
- Report date:
- 1996
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Version / remarks:
- 1984
- Deviations:
- no
- GLP compliance:
- no
Test material
- Reference substance name:
- Dibutyl adipate
- EC Number:
- 203-350-4
- EC Name:
- Dibutyl adipate
- Cas Number:
- 105-99-7
- Molecular formula:
- C14H26O4
- IUPAC Name:
- dibutyl adipate
- Test material form:
- liquid
Constituent 1
Sampling and analysis
- Analytical monitoring:
- no
Test solutions
- Vehicle:
- yes
- Details on test solutions:
- Stock solution was prepared with DMSO:HCO-40 = 9:1 (100 mg/l). Controls with and without this vehicle were taken for the test.
Test organisms
- Test organisms (species):
- Daphnia magna
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 24 h
Test conditions
- Nominal and measured concentrations:
- 20 daphnids (4 replicates; 5 organisms per replicate) were exposed to each of 5 nominal concentrations (5.6-56 mg/l).
- Details on test conditions:
- TEST SYSTEM
- Type: open - Reference substance (positive control):
- yes
Results and discussion
Effect concentrations
- Key result
- Duration:
- 24 h
- Dose descriptor:
- EC50
- Effect conc.:
- ca. 17 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
Any other information on results incl. tables
Daphnia
Type of test: static [X]; semi-static [ ]; flow-through [ ]; other [ ];
open-system [X]; closed-system [ ]
Species: Daphnia magna
Exposure period: 24 hr
Results: EC50 (24h) = 17 mg/l
Analytical monitoring: Yes [ ] No [X] ? [ ]
Method: OECD Test Guideline 202 (1984)
GLP: Yes [ ] No [X] ? [ ]
Test substance: Dibutyl adipate, purity: = 99 %
Remarks: 20 daphnids (4 replicates; 5 organisms per replicate) were
exposed to each of 5 nominal concentrations (5.6-56 mg/l).
Stock solution was prepared with DMSO:HCO-40 = 9:1
(100 mg/l). Controls with and without this vehicle were taken
for the test.
Reference: EA, Japan (1994)
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
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