[ethane-1,2-diylbis[nitrilobis(methylene)]]tetrakisphosphonic acid

Particle size distribution (Granulometry)

Link to relevant study record(s)

Reference

Endpoint:

particle size distribution (granulometry)

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

guideline study with acceptable restrictions

Remarks:

The study was conducted using an acceptable method but not in compliance with GLP.

Principles of method if other than guideline:

The particle size distribution was performed by weighing sieves with defined mesh numbers before and after the sieving process.

GLP compliance:

no

Type of method:

sieving

Type of particle tested:

aggregate

Type of distribution:

mass based distribution

Key result

Percentile:

D50

Mean:

ca. 218 - ca. 321 µm

Remarks on result:

other: Mean particle size distribution for three samples

No.:

#1

Size:

< 100 µm

Distribution:

ca. 1.3 - ca. 3.7 %

Remarks on result:

other: Particle size distribution of samples 1 to 3

No.:

#2

Size:

< 45 µm

Distribution:

ca. 0 - ca. 0.2 %

Remarks on result:

other: Particle size distribution of samples 1 to 3

Results:

Table 1: sample 1

Sieve (µm)	Percentage (%)	Particle size (µm)	Sum (%)
500	30.0	>500	100.0
400	6.3	<500	70.0
250	28.1	<400	63.8
200	16.0	<250	35.7
125	17.2	<200	19.7
100	1.1	<125	2.5
63	1.0	<100	1.3
45	0.3	<63	0.3
Bottom	0.0	<45	0.0
Total	100.0	0	0.0

 

Mean particle size (DT50) = 318 µm

Table 2: sample 2

Sieve (µm)	Percentage (%)	Particle size (µm)	Sum (%)
500	12.2	>500	100.0
400	18.5	<500	87.8
250	41.5	<400	69.3
200	10.7	<250	27.8
125	13.8	<200	17.0
100	1.3	<125	3.2
63	1.5	<100	1.9
45	0.3	<63	0.4
Bottom	0.1	<45	0.1
Total	100.0	0	0.0

 

Mean particle size (DT50) = 321 µm

Table 3: sample 3

Sieve (µm)	Percentage (%)	Particle size (µm)	Sum (%)
500	2.7	>500	100.0
400	5.5	<500	97.3
250	22.7	<400	91.8
200	31.3	<250	69.1
125	31.3	<200	37.8
100	2.8	<125	3.7
63	3.2	<100	3.7
45	0.4	<63	0.5
Bottom	0.2	<45	0.2
Total	100.0	0	0.0

 

Mean particle size (DT50) = 218 µm

The particle size distribution was calculated from average of three independent determinations.

Conclusions:

A mean particle size distribution (DT50) of 218 - 321 µm, with 1.3 - 3.7% of the samples <100 µm, and 0 - 0.02% of the samples <45 µm was determined for the substance. The result is considered reliable.

Description of key information

Mean particle size: 218 - 321 µm, <100 µm = 1.3 - 3.7% and <45 µm = 0 - 0.2%

Additional information

The particle size distribution of the substance was determined using the sieving method. A mean particle size distribution (DT₅₀) of 218 -321 µm was determined for three samples of the substance. Similarly, about 1.3 - 3.7% of the samples were <100 µm and 0 - 0.02% <45 µm.