Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Classification & Labelling & PBT assessment

PBT assessment

Administrative data

Assessed Substance

Assessed substance:
substance itself
Reference substance name:
IUPAC name:
nonafluorobutane-1-sulfonic acid
Inventory number:
InventoryMultipleMappingImpl [inventoryEntryValue=EC 206-793-1]
CAS number:
1-Butanesulfonic acid, 1,1,2,2,3,3,4,4,4-nonafluoro-
1,1,2,2,3,3,4,4,4-nonafluorobutane-1-sulfonic acid
Molecular formula:
Molecular weight:
SMILES notation:
PFBS pure
Type of composition:
legal entity composition of the substance
State / form:
Reference substance:
PFBS pure
PBT status of the assessed substance:
the substance is not PBT / vPvB

Results of detailed PBT / vPvB assessment


Evidence of non-P / non-vP properties
Screening criteria
Criteria based on Annex XIII of REACH
Further information for the PBT assessment is necessary
PFBS is not expected to biodegrade or to undergo hydrolysis or photolysis. The substance is not readily biodegradable.
Conclusion on P / vP properties:
vP (and P)


Evidence of non-B / non-vB properties
Screening criteria
Not B and not vB based on: Log Kow ≤ 4.5
The substance shows a high water solubility of 50g/L
Criteria based on Annex XIII of REACH
Further information for the PBT assessment is necessary
Bioaccumulation of PFBS has been studied and a number of reports are available in literature. Bioconcentration factors ranging from 0.30 to 1.44 have been reported, well below the REACH criteria of 2000 for B and 5000 for vB, respectively.
Conclusion on B / vB properties:
not B/vB


Evidence of non-T properties
Criteria based on Annex XIII of REACH
Not T based on:
EC10 or NOEC ≥ 0.01 mg/L for marine / freshwater organisms (long-term toxicity):
The 48-hour EC50 of PFBSK+ to Daphnia magna was examined in a static test conducted according to EPA 850.1010 and OECD TG 202. 20% cumulative immobilization was observed at 1707 mg/L, and 100% cumulative immobilization was observed at 9433 mg/L. The 48-hour EC50 was determined as 2183 mg/L.
Additional studies are available for long term aquatic and terrestric toxicity of PFBS, which show that NOEC values are well above the toxicity threshold of 0.01 mg/L.
and substance is not classified as carcinogenic (category 1 or 2), mutagenic (category 1 or 2), or toxic for reproduction (category 1, 2 or 3) according to Directive 67/548/EEC or carcinogenic (category 1A or 1B), germ cell mutagenic (category 1A or 1B), or toxic for reproduction (category 1A, 1B or 2) according to Regulation EC No 1272/2008:
Sufficient long term data data are available for the source substance PFBSK+ which indicate that it is not to be classified as CMR Cat 1 or 2. Read across of this property to the target substance PFBS is valid for long term endpoints.
Other evidence of non-T properties
2-hour EC50 of PFBSK+ to Pseudokirchneriella subcapitata was 5661 mg a.i./L
Evidence of T properties
Conclusion on T properties:
not T