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EC number: 412-180-1 | CAS number: 10221-57-5 1,2-DIETHOXYPROPANE; DIETHOXY-1,2-PROPANE
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 16th July 1991 - 2nd December 1991
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 991
- Report date:
- 1991
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- 1,2-diethoxypropane
- EC Number:
- 412-180-1
- EC Name:
- 1,2-diethoxypropane
- Cas Number:
- 10221-57-5
- Molecular formula:
- C7H16O2
- IUPAC Name:
- 1,2-diethoxypropane
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River (UK) Limited, Manston Road, Margate, Kent
- Females (if applicable) nulliparous and non-pregnant: Yes
- Age at study initiation: 6-8 weeks old
- Weight at study initiation: 171-216 g
- Fasting period before study: Yes; overnight prior to dosing and 3 h post dosing
- Housing: polypropylene cages with mesh floors suspended over absorbent paper lined trays, with a maximum of 5 animals per cage.
- Diet: Rat and Mouse No. 1 Maintenance Diet, supplied by Special Diets Services, 1 Stepfield, Witham, Essex, CM8 3AD ad libitum
- Water: Tap water ad libitum
- Acclimination: 7 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 19-21°C mean relative humidity was 55%.
- Humidity (%): Mean relative humidity was 55%
- Photoperiod (hrs dark / hrs light): A 12 h light/dark cycle was in operation
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: Tween 80
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 200 mg/mL
MAXIMUM DOSE VOLUME APPLIED: 10mL/kg
- Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- 5 males
5 females - Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: Observed frequently on the day of dosing and once daily for 14 days following dosing.
- Frequency of weighing: They were weighed immediately prior to dosing, 7 days after dosing and at sacrifice at the end of the 14 day observation period.
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Mortality:
- There were no deaths.
- Clinical signs:
- other: Clinical signs were noted 30 mins - 4 hrs after dosing, included piloerection, soiled coat, reduced activity, ataxia and subdued behaviour.
- Gross pathology:
- There were no abnormalities detected at necropsy.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- In an acute oral toxicity study in Sprague Dawley rats the LD50 (male/female) was >2000 mg/kg bw.
- Executive summary:
In an acute oral toxicity study (8279), groups (5/sex) of Sprague Dawley rats were given a single oral dose of 1,2-Diethoxypropane in Tween-80 by gavage at 2000 mg/kg bw. Animals were then observed for 14 days.
LD50 (male/female): > 2000 mg/kg bw.
Clinical signs were noted 30 mins - 4 hrs after dosing, included piloerection, soiled coat, reduced activity, ataxia and subdued behaviour. There was no mortality and no abnormalities were detected at necropsy. Body weight gains were acceptable.
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