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EC number: 701-349-8 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Density
Administrative data
Link to relevant study record(s)
- Endpoint:
- relative density
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 19 July 2017 - 01 June 2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Remarks:
- Study was conducted in accordance with international guidelines and in accordance with GLP. All guideline validity criteria were met.
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.3 (Relative Density)
- Version / remarks:
- Regulation (EC) 440/2008 of 30 May 2008
- Deviations:
- yes
- Remarks:
- Study was performed at 19.5 °C not 20.0 °C (as per guideline). Typical thermal expansion coefficients of solids and the volumetric expansion of stainless steel are of the order of 10-5 °C-1. A temperature delta of 0.5 °C is expected to be negligible.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 109 (Density of Liquids and Solids)
- Version / remarks:
- 02 October 2012
- Deviations:
- yes
- Remarks:
- Study was performed at 19.5 °C not 20.0 °C (as per guideline). Typical thermal expansion coefficients of solids and the volumetric expansion of stainless steel are of the order of 10-5 °C-1. A temperature delta of 0.5 °C is expected to be negligible.
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- air comparison pycnometer (for solids)
- Key result
- Type:
- relative density
- Density:
- 1.01 other: Dimensionless.
- Temp.:
- 19.5 °C
- Remarks on result:
- other: Study was performed at 19.5 °C not 20.0 °C (as per guideline).
- Remarks:
- Typical thermal expansion coefficients of solids and the volumetric expansion of stainless steel are of the order of 10-5 °C-1. A temperature delta of 0.5 °C is expected to be negligible.
- Conclusions:
- The density of the test item has been determined to be 1.01 x 103 kg/m3 at 19.5 ± 0.5 °C (relative density: 1.01).
- Executive summary:
EU Method A.3. – The relative density of the test item was determined utilising an gas comparison pycnometer. The procedure employed was designed to be compatible with Method A.3., Relative Density, of Commission Regulation (EC) No 440/2008 of 30 May 2008.
Two determinations were carried out. An instrumentation check was performed by measuring of the volume of the reference sphere. Aliquots of test item (22.5 – 24.0 g) were placed in the measuring cell. The density of the test item was determined. This determination was performed in triplicate at 19.5 °C ± 0.5 °C to acquire a mean value.
The relative density (D420) of the test item was calculated to be 1.01, based on the ratio of the measured density of the test item relative to the density of water a 4 °C i.e.;
D420 = densitytest item/densitywater
where:
test item = density of test item at 19.5 °C (g/cm3)
water = density of water at 4.0 °C (g/cm3)
Note: The mass density of a substance varies with temperature and pressure and this variance is typically negligible for solids. Typical thermal expansion coefficients of solids are in the order of 10-5 °C-1, and the volumetric expansion of stainless steel (used as calibration spheres) at 20 °C is approximately 5.2 x 10-5 °C-1. Thus, a change in temperature of several degrees will have no significant effect on the volume and hence the density of a solid substance. It was considered that the difference in temperature between 20.0 °C and normal laboratory conditions did not have a significant effect on the determined density, and therefore the calculated relative density.
Reference
Evaluation of Data:
The density of a substance is the quotient of the mass and the volume of that substance at a specific temperature. The SI unit is kg/m³. 1 g/cm³ corresponds to 1000 kg/m³. The density (ρ) of the test item was calculated using the following equations:
Equation 1:
Vref= Vcal/(P1/P2– P3/P4)
Equation 2:
Vcell= Vref. ((P1/P2) - 1)
Equation 3:
Vsample= Vcell– Vref. ((P1(sample)/P2(sample)) - 1)
Equation 4:
row = 1000 m/Vsample
where:
P1, P2= Pressure readings in the calibration procedure without calibration sphere (psig)
P3, P4= Pressure readings in the calibration procedure with calibration sphere (psig)
P1(sample), P2(sample)= Pressure readings with the sample cell containing test item (psig)
Vcal= Volume of the calibration sphere (cm3)
Vref= Volume of the reference cell (cm³)
Vcell= Volume of the sample cell (cm³)
Vsample= Volume of the test item (cm³)
m = Mass of test item (g)
The relative density of solids or liquids is the ratio between the mass of a volume of substance to be examined determined at 20 °C, and the mass of the same volume of water determined at 4 °C. Relative density has no dimensions. The density of water determined at 4 °C is 999.97 kg/m3 (as published by the CRC Handbook of Chemistry and Physics, 94th Edition 2013-2014). The relative density (D204) was calculated using the following equation:
Equation 5:
D204= ρ / (999.97 kg/m3)
Calibration:
The pressure readings and the calculated volume for the reference and sample cells are shown in the following table:
Table 2:
Determination |
P1(psig) |
P2(psig) |
P3(psig) |
P4(psig) |
Reference cell volume (cm3) |
Sample cell volume (cm3) |
1 |
17.246 |
6.528 |
17.260 |
8.554 |
90.628 |
148.797 |
2 |
17.209 |
6.516 |
17.325 |
8.586 |
90.753 |
148.929 |
3 |
17.200 |
6.514 |
17.202 |
8.523 |
90.907 |
149.130 |
Mean |
90.763 |
148.952 |
Vcal = 56.559 cm3
Calibration was performed at 18.9 ± 0.5 °C
As the reference cell volume and sample cell volume were within the defined tolerance (90.953 ± 1.0 cm3 and 149.225 ± 1.0 cm3 for the reference and sample cell volumes respectively) the gas comparison pycnometer was therefore considered acceptable for use.
Density Determination:
The pressure readings, calculated volumes and density values obtained for the test item are shown in Table 3:
Table 3:
Determination |
Test |
P1(sample)(psig) |
P2(sample)(psig) |
Volume (cm3) |
Density (kg/m3) |
Mean density (kg/m3) |
1 |
A |
17.002 |
7.106 |
22.554 |
1.002 x 103 |
1.005 x 103 |
B |
17.026 |
7.115 |
22.522 |
1.004 x 103 |
||
C |
17.026 |
7.113 |
22.461 |
1.006 x 103 |
||
2 |
A |
17.025 |
7.159 |
23.870 |
1.006 x 103 |
1.006 x 103 |
B |
17.011 |
7.153 |
23.866 |
1.006 x 103 |
||
C |
16.987 |
7.142 |
23.839 |
1.007 x 103 |
Sample determinations were performed at 19.5 ± 0.5 °C
Vcal = 56.559 cm3
Mean density : 1.01 x 103 kg/m3
Relative density : 1.01
Temperature : 19.5 ± 0.5 °C
Discussion:
Duplicate determinations were performed to ensure a reproducibility of less than ± 20 kg/m3 was obtained.
The mass density of a substance varies with temperature and pressure and this variance is typically negligible for solids. Increasing the temperature of a substance may decrease its density by increasing the volume of that substance. Typical thermal expansion coefficients of solids are in the order of 10-5 °C-1, and the volumetric expansion of stainless steel (used as calibration spheres) at 20 °C is approximately 5.2 x 10-5 °C-1. Therefore, a change in temperature of several degrees will have no significant effect on the volume and hence the density of a solid substance. Therefore, it was considered that the difference in temperature between 20.0 °C and normal laboratory conditions did not have a significant effect on the determined density, and therefore the calculated relative density.
Conclusion:
The density of the test item has been determined to be 1.01 x 103 kg/m3 at 19.5 ± 0.5 °C (relative density: 1.01).
Description of key information
Density: Relative Density = 1.01; EU Method A.3.; R. Butler (2018)
Key value for chemical safety assessment
- Relative density at 20C:
- 1.01
Additional information
EU Method A.3. – The relative density of the test item was determined utilising an gas comparison pycnometer. The procedure employed was designed to be compatible with Method A.3., Relative Density, of Commission Regulation (EC) No 440/2008 of 30 May 2008.
Two determinations were carried out. An instrumentation check was performed by measuring of the volume of the reference sphere. Aliquots of test item (22.5 – 24.0 g) were placed in the measuring cell. The density of the test item was determined. This determination was performed in triplicate at 19.5 °C ± 0.5 °C to acquire a mean value.
The relative density (D420) of the test item was calculated to be 1.01, based on the ratio of the measured density of the test item relative to the density of water a 4 °C i.e.;
D420 = densitytest item/densitywater
where:
test item = density of test item at 19.5 °C (g/cm3)
water = density of water at 4.0 °C (g/cm3)
Note: The mass density of a substance varies with temperature and pressure and this variance is typically negligible for solids. Typical thermal expansion coefficients of solids are in the order of 10-5 °C-1, and the volumetric expansion of stainless steel (used as calibration spheres) at 20 °C is approximately 5.2 x 10-5 °C-1. Thus, a change in temperature of several degrees will have no significant effect on the volume and hence the density of a solid substance. It was considered that the difference in temperature between 20.0 °C and normal laboratory conditions did not have a significant effect on the determined density, and therefore the calculated relative density.
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