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EC number: 701-349-8 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Vapour pressure
Administrative data
Link to relevant study record(s)
- Endpoint:
- vapour pressure
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 19 July 2017 - 18 May 2018
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Remarks:
- Study was conducted in accordance with international guidelines and in accordance with GLP. Not all experimental validity criteria were met. The test item was determined to have a vapour pressure that was too low to achieve reliable and repeatable measurement. As a consequence statistical analysis was not possible. A worst case limit value, based on a measured data point and historical lab data, was determined and reported.
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.4 (Vapour Pressure)
- Version / remarks:
- Regulation (EC) 440/2008 of 30 May 2008
- Deviations:
- yes
- Remarks:
- Due to methodological limitations and the properties of the test item, only one vapour pressure value (at 25 °C) was determined.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 104 (Vapour Pressure Curve)
- Version / remarks:
- 23 March 2006
- Deviations:
- yes
- Remarks:
- Due to methodological limitations and the properties of the test item, only one vapour pressure value (at 25 °C) was determined.
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- effusion method: vapour pressure balance
- Key result
- Temp.:
- 25 °C
- Vapour pressure:
- < 0.01 Pa
- Remarks on result:
- other: Limit Value
- Remarks:
- See discussion.
- Key result
- Transition / decomposition:
- no
- Conclusions:
- The vapour pressure of the test item has been determined to be less than 1.0 x 10-2Pa at 25°C.
- Executive summary:
EU Method A.4. – The vapour pressure of the test item was sought using the vapour pressure balance method. The procedure employed was designed to be compatible with Method A.4. Vapour Pressure of Commission Regulation (EC) No 440/2008 of 30 May 2008.
The test item was subject to a sequence of runs to determine vapour pressure. A sample of test item was held under vacuum for approximately 20 hours. Temperature and mass differential readings were measured across a temperature range of39 and 49°C following the outcome of a preliminary test. Values measured across this temperature range showed a poor linear response.
In light of the poor linear response of the test item to experimental conditions, no statistical analyses were performed because the readings were too variable for a line of best fit to have any meaning. It was considered more appropriate to impose a regression slope on a chosen data point to provide an estimate of the maximum value for the vapour pressure at 25°C. This methodology was applied to a reading at 40°C (313 K) obtained during the final test run. This value was chosen as the test item had been under vacuum for the longest period prior to this run and so degassing would have been the most complete. Further this temperature resulted in the highest estimated vapour pressure at any given temperature when a slope of –1000 K is imposed upon it. The value of –1000 K is an in-house laboratory value. It is the shallowest slope observed whilst determining the vapour pressure on a wide range of samples using the vapour pressure balance method. Extrapolation to 25°C gave a vapour pressure of 9.95 x 10-3Pa which has been taken as a maximum for this substance.
A vapour pressure limit value of the test item has been determined to be 9.95 x 10-3 Pa at 25 °C.
Reference
Evaluation of Data:
The vapour pressure is related to the observed mass difference using Equation 1:
Equation 1:
Vp= (δm.g)/A
Where:
Vp = vapour pressure (Pa)
δm = mass difference (kg)
g = acceleration due to gravity (9.813 m s-2)
A = area of the orifice (7.06858 x 10-6m2)
Vapour pressure is related to temperature using Equation 2:
Log10Vp= slope/T + intercept
Where
Vp = vapour pressure (Pa)
T = temperature (K)
A plot of Log10 Vp(Pa) versus reciprocal temperature (1/T(K)) therefore gives a straight-line graph.
The vapour pressure of the sample was measured over a range of temperatures to enable extrapolation to 298.15 K.
Results:
Recorded temperatures, mass differences and the resulting calculated values of vapour pressure are shown in the following tables:
Table 1: Vapour Pressure Data, Run 7
Temperature |
Temperature |
Reciprocal Temperature |
Mass Difference |
Mass Difference |
Vapour Pressure |
Log10Vp |
°C |
K |
K-1 |
µg |
kg |
Pa |
|
39 |
312.15 |
0.0032036 |
13.88 |
1.388 x 10-8 |
0.0192690 |
-1.715141 |
40 |
313.15 |
0.0031934 |
9.58 |
9.580 x 10-9 |
0.0132995 |
-1.876165 |
41 |
314.15 |
0.0031832 |
6.89 |
6.890 x 10-9 |
0.0095651 |
-2.019311 |
42 |
315.15 |
0.0031731 |
7.49 |
7.490 x 10-9 |
0.0103980 |
-1.983049 |
43 |
316.15 |
0.0031631 |
6.69 |
6.690 x 10-9 |
0.0092874 |
-2.032104 |
44 |
317.15 |
0.0031531 |
8.69 |
8.690 x 10-9 |
0.0120639 |
-1.918511 |
45 |
318.15 |
0.0031432 |
6.59 |
6.590 x 10-9 |
0.0091486 |
-2.038645 |
46 |
319.15 |
0.0031333 |
8.59 |
8.590 x 10-9 |
0.0119251 |
-1.923537 |
47 |
320.15 |
0.0031235 |
9.09 |
9.090 x 10-9 |
0.0126192 |
-1.898966 |
48 |
321.15 |
0.0031138 |
8.39 |
8.390 x 10-9 |
0.0116475 |
-1.933768 |
49 |
322.15 |
0.0031041 |
9.29 |
9.290 x 10-9 |
0.0128969 |
-1.889515 |
No statistical analysis is given due to the nature of the plot.
Table 2: Vapour Pressure Data, Run 8
Temperature |
Temperature |
Reciprocal Temperature |
Mass Difference |
Mass Difference |
Vapour Pressure |
Log10Vp |
°C |
K |
K-1 |
µg |
kg |
Pa |
|
39 |
312.15 |
0.0032036 |
15.08 |
1.508 x 10-8 |
0.0209349 |
-1.679129 |
40 |
313.15 |
0.0031934 |
8.39 |
8.390 x 10-9 |
0.0116475 |
-1.933768 |
41 |
314.15 |
0.0031832 |
7.09 |
7.090 x 10-9 |
0.0098427 |
-2.006884 |
42 |
315.15 |
0.0031731 |
7.29 |
7.290 x 10-9 |
0.0101204 |
-1.994803 |
43 |
316.15 |
0.0031631 |
7.09 |
7.090 x 10-9 |
0.0098427 |
-2.006884 |
44 |
317.15 |
0.0031531 |
6.29 |
6.290 x 10-9 |
0.0087321 |
-2.058880 |
45 |
318.15 |
0.0031432 |
7.19 |
7.190 x 10-9 |
0.0099816 |
-2.000801 |
46 |
319.15 |
0.0031333 |
7.89 |
7.890 x 10-9 |
0.0109533 |
-1.960453 |
47 |
320.15 |
0.0031235 |
8.89 |
8.890 x 10-9 |
0.0123416 |
-1.908629 |
48 |
321.15 |
0.0031138 |
7.29 |
7.290 x 10-9 |
0.0101204 |
-1.994803 |
49 |
322.15 |
0.0031041 |
7.59 |
7.590 x 10-9 |
0.0105369 |
-1.977289 |
No statistical analysis is given due to the nature of the plot.
Table 3: Vapour Pressure Data, Run 9
Temperature |
Temperature |
Reciprocal Temperature |
Mass Difference |
Mass Difference |
Vapour Pressure |
Log10Vp |
°C |
K |
K-1 |
µg |
Kg |
Pa |
|
39 |
312.15 |
0.0032036 |
14.78 |
1.478 x 10-8 |
0.0205184 |
-1.687856 |
40 |
313.15 |
0.0031934 |
9.19 |
9.190 x 10-9 |
0.0127581 |
-1.894215 |
41 |
314.15 |
0.0031832 |
7.19 |
7.190 x 10-9 |
0.0099816 |
-2.000801 |
42 |
315.15 |
0.0031731 |
9.09 |
9.090 x 10-9 |
0.0126192 |
-1.898966 |
43 |
316.15 |
0.0031631 |
7.89 |
7.890 x 10-9 |
0.0109533 |
-1.960453 |
44 |
317.15 |
0.0031531 |
7.79 |
7.790 x 10-9 |
0.0108145 |
-1.965993 |
45 |
318.15 |
0.0031432 |
7.99 |
7.990 x 10-9 |
0.0110922 |
-1.954984 |
46 |
319.15 |
0.0031333 |
7.39 |
7.390 x 10-9 |
0.0102592 |
-1.988886 |
47 |
320.15 |
0.0031235 |
8.19 |
8.190 x 10-9 |
0.0113698 |
-1.944246 |
48 |
321.15 |
0.0031138 |
7.49 |
7.490 x 10-9 |
0.0103980 |
-1.983049 |
49 |
322.15 |
0.0031041 |
7.59 |
7.590 x 10-9 |
0.0105369 |
-1.977289 |
No statistical analysis is given due to the nature of the plot.
Table 4: Vapour Pressure Data, Run 10
Temperature |
Temperature |
Reciprocal Temperature |
Mass Difference |
Mass Difference |
Vapour Pressure |
Log10Vp |
°C |
K |
K-1 |
µg |
kg |
Pa |
|
39 |
312.15 |
0.0032036 |
8.49 |
8.490 x 10-9 |
0.0117863 |
-1.928623 |
40 |
313.15 |
0.0031934 |
10.38 |
1.038 x 10-8 |
0.0144101 |
-1.841333 |
41 |
314.15 |
0.0031832 |
6.99 |
6.990 x 10-9 |
0.0097039 |
-2.013053 |
42 |
315.15 |
0.0031731 |
6.59 |
6.590 x 10-9 |
0.0091486 |
-2.038645 |
43 |
316.15 |
0.0031631 |
6.09 |
6.090 x 10-9 |
0.0084545 |
-2.072913 |
44 |
317.15 |
0.0031531 |
6.49 |
6.490 x 10-9 |
0.0090098 |
-2.045286 |
45 |
318.15 |
0.0031432 |
6.99 |
6.990 x 10-9 |
0.0097039 |
-2.013053 |
46 |
319.15 |
0.0031333 |
6.19 |
6.190 x 10-9 |
0.0085933 |
-2.065840 |
47 |
320.15 |
0.0031235 |
7.09 |
7.090 x 10-9 |
0.0098427 |
-2.006884 |
48 |
321.15 |
0.0031138 |
7.19 |
7.190 x 10-9 |
0.0099816 |
-2.000801 |
49 |
322.15 |
0.0031041 |
8.59 |
8.590 x 10-9 |
0.0119251 |
-1.923537 |
No statistical analysis is given due to the nature of the plot.
Discussion:
The appearance of the test item did not change under the conditions used in the determination.
No statistical analyses were performed because the balance readings were too low and variable for a line of best fit to have any meaning. Instead it was considered more appropriate to impose a regression slope on a chosen data point to provide an estimate of the maximum value for the vapour pressure at 25 ºC. Runs 7 to 10 have been included to demonstrate the behaviour of the test item under the test conditions; Runs 1 to 6 were similar and no statistical analysis could be obtained due to the nature of these plots.
Run 10 was chosen because the sample had been under vacuum for the longest period prior to this run and so degassing would have been the most complete. The reading at 40 ºC (313 K) was chosen because this is the data point which gives the highest estimated vapour pressure at any given temperature when a slope of –1000 K is imposed upon it.
The value of –1000 K is an in-house value and is the shallowest slope observed whilst determining the vapour pressure on a wide range of samples using the vapour pressure balance method. Extrapolation to 25 ºC gave a vapour pressure of 9.95 x 10-3 Pa which has been taken as a maximum for this substance.
The results may represent rounded values obtained by calculations based on the exact raw data.
Conclusion:
The vapour pressure of the test item has been determined to be less than 1.0 x 10-2Pa at 25°C.
Description of key information
Vapour Pressure: < 1.0 x 10-2 Pa at 25 ºC.; EU Method A.4.; R. Butler (2018)
Key value for chemical safety assessment
- Vapour pressure:
- 0.01 Pa
- at the temperature of:
- 25 °C
Additional information
EU Method A.4. – The vapour pressure of the test item was sought using the vapour pressure balance method. The procedure employed was designed to be compatible with Method A.4. Vapour Pressure of Commission Regulation (EC) No 440/2008 of 30 May 2008.
The test item was subject to a sequence of runs to determine vapour pressure. A sample of test item was held under vacuum for approximately 20 hours. Temperature and mass differential readings were measured across a temperature range of 39 and 49°C following the outcome of a preliminary test. Values measured across this temperature range showed a poor linear response.
In light of the poor linear response of the test item to experimental conditions, no statistical analyses were performed because the readings were too variable for a line of best fit to have any meaning. It was considered more appropriate to impose a regression slope on a chosen data point to provide an estimate of the maximum value for the vapour pressure at 25°C. This methodology was applied to a reading at 40°C (313 K) obtained during the final test run. This value was chosen as the test item had been under vacuum for the longest period prior to this run and so degassing would have been the most complete. Further this temperature resulted in the highest estimated vapour pressure at any given temperature when a slope of –1000 K is imposed upon it. The value of –1000 K is an in-house laboratory value. It is the shallowest slope observed whilst determining the vapour pressure on a wide range of samples using the vapour pressure balance method. Extrapolation to 25°C gave a vapour pressure of 9.95 x 10-3Pa which has been taken as a maximum for this substance.
A vapour pressure limit value of the test item has been determined to be < 1.0 x 10 -2 Pa at 25 °C.
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